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Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism

机译：通过下调Cyclin D1和通过AMPK-α独立机制来提高原发性乳腺癌细胞中凋亡的凋亡

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期刊名称 Turkish Journal of Medical Sciences
作者
Güven YENMİŞ; Nail Beşli; Elif YAPRAK SARAÇ; Fatma Sinem HOCAOĞLU EMRE; Kazım ŞENOL; Gönül KANIGÜR SULTUYBEK;
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年(卷),期 2021(51),2
年度 2021
页码 826–834
总页数 9
原文格式 PDF
正文语种
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关键词

机译：AMPK-alpha;Cyclin D1;TP53;乳腺癌;二甲双胍;

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专利

1. Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein. [J] . Yoshida T, Zhang Y, Rivera Rosado LA, Molecular cancer therapeutics . 2010,第6期

机译：Rac1活性的阻断通过下调细胞周期蛋白D1，survivin和X连锁的凋亡蛋白抑制剂诱导乳腺癌细胞G1周期停滞或凋亡。
2. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1 [J] . Yongxian Zhuang, W Keith Miskimins Journal of molecular signaling . 2008,第1期

机译：二甲双胍治疗的乳腺癌细胞的细胞周期停滞涉及AMPK的激活，细胞周期蛋白D1的下调，并需要p27Kip1或p21Cip1
3. Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1 [J] . Vadde Ramakrishna, Radhakrishnan Sridhar, Kurundu Hewage Eranda Karunathilake, Journal of Functional Foods . 2016,第Null期

机译：印度醋栗（Emblica officinalis Gaertn。）通过抑制c-Myc和cyclin D1抑制细胞增殖并诱导人结肠癌干细胞凋亡，而与p53状态无关
4. Induction of apoptosis in p53-deficient L1210cells by an I-К-B-α-inhibitor (Bay 11-7085)via a NF-К-B-independent mechanism [C] . Ann H. Cory, Joseph G. Cory International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2005

机译：通过NF-к-b-β-抑制剂（Bay 11-7085）通过NF-к-B-B-B-B-B-B-β-β-抑制剂诱导P53缺陷L1210Cells的凋亡
5. DLX4 homeoprotein promotes PI3K/Akt anti-apoptosis pathway in ER negative breast cancer cells through upregulation of VEGFA. [D] . Wu, Weiwei. 2010

机译：DLX4同源蛋白通过上调VEGFA促进ER阴性乳腺癌细胞中的PI3K / Akt抗凋亡途径。
6. Overexpression of the Ubiquitin-Specific Peptidase 9 X-Linked (USP9X) Gene is Associated with Upregulation of Cyclin D1 (CCND1) and Downregulation of Cyclin-Dependent Inhibitor Kinase 1A (CDKN1A) in Breast Cancer Tissue and Cell Lines [O] . Hang Li, Bin Zheng 2019

机译：泛素特异性肽酶9 X连锁（USP9X）基因的过表达与乳腺癌组织和细胞株中细胞周期蛋白D1（CCND1）的上调和细胞周期蛋白依赖性抑制剂激酶1A（CDKN1A）的下调相关。
7. Overexpression of the Ubiquitin-Specific Peptidase 9 X-Linked (USP9X) Gene is Associated with Upregulation of Cyclin D1 (CCND1) and Downregulation of Cyclin-Dependent Inhibitor Kinase 1A (CDKN1A) in Breast Cancer Tissue and Cell Lines [O] . Hang Li, Bin Zheng 2019

机译：泛素特异性肽酶9 X-连接（USP9x）基因的过表达与细胞周期蛋白D1（CCND1）的上调和在乳腺癌组织和细胞系中的细胞周期蛋白依赖性抑制剂激酶1A（CDKN1A）的下调相关。
8. Cohort Study of the Relationship Between c-erbB-2 and Cyclin D1 Overexpression, p53 Mutation and/or Protein Accumulation, and Risk of Progression from Benign Breast Disease to Breast Cancer; and Creation of a Bank of Benign Breast Tissue [R] . Kandel, R. A. , Rohan, T. 2002

机译：队列研究c-erbB-2和细胞周期蛋白D1过表达，p53突变和/或蛋白质积累，以及从良性乳腺疾病进展到乳腺癌的风险;和创建良性乳腺组织

Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism

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