Discoveryof Potent and Selective Antibody–DrugConjugates with Eg5 Inhibitors through Linker and Payload Optimization

著录项

• 期刊名称 ACS Medicinal Chemistry Letters
• 作者

  AlexeiS. Karpov; Cristina M. Nieto-Oberhuber; Tinya Abrams; Edwige Beng-Louka; Enrique Blanco; Sylvie Chamoin; Patrick Chene; Isabelle Dacquignies; Dylan Daniel; ∥; Michael P. Dillon; ⊥; Lionel Doumampouom-Metoul; Nikolaos Drosos; Pavel Fedoseev; Markus Furegati; Brian Granda; Robert M. Grotzfeld; Suzanna Hess Clark; Emilie Joly; Darryl Jones; Marion Lacaud-Baumlin; Stephanie Lagasse-Guerro; Edward G. Lorenzana; #; William Mallet; ∇; Piotr Martyniuk; Andreas L. Marzinzik; Yannick Mesrouze; Sandro Nocito; Yoko Oei; □; Francesca Perruccio; Grazia Piizzi; ○; Etienne Richard; Patrick J. Rudewicz; Patrick Schindler; Mélanie Velay; Kristine Venstrom; Peiyin Wang; □; Mauro Zurini; Marc Lafrance; *;

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• 作者单位

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• 年(卷),期 2019(10),12
• 年度 2019
• 页码 1674–1679
• 总页数 6
• 原文格式 PDF
• 正文语种
• 中图分类 药物化学;
• 关键词

  Antibody−drug conjugate (ADC); HER2; c-KIT; antimitotic; kinesin spindle protein (Eg5KSP1; KIF11);

  机译：抗体 - 药物缀合物（ADC）;HER2;C-kit;抗苷;Kinesin主轴蛋白（EG5;KSP1;KIF11）;