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ACS Medicinal Chemistry Letters

【机译】：aCs药物化学快报

ISSN：-
出版周期：Monthly
语言：English

起始发布年份：2009
出版者：Washington, D.C. : American Chemical Society
出版地：United States

NLM刊名缩写：ACS Med Chem Lett

数据库引入：PubMed: v1, 2010-, PMC

MeSH词表主题词：Chemistry, Pharmaceutical*

备注：Description based on: Vol. 1, issue 1 (April 2010); title from editorial PDF page展开▼

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1.Potent Long-Acting Cyclopentane-13-DioneThromboxane(A2)-Receptor Antagonists

机译：强效长效环戊烷-13-二酮血栓烷（A2）-受体拮抗剂
- 作者：Xiaozhao Wang;Li Liu;Longchuan Huang;Katie Herbst-Robinson;Anne-Sophie Cornec;MichaelJ. James;Shimpei Sugiyama;Marcella Bassetto;Andrea Brancale;JohnQ. Trojanowski;Virginia M.-Y. Lee;Amos B. Smith III;Kurt R. Brunden;*;Carlo Ballatore;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第9期
- Cyclopentane-13-dione;
- carboxylic acid bioisostere;
- thromboxane A2;
- thromboxane receptor antagonists;
2.Discovery of a Dual PRMT5–PRMT7 Inhibitor

机译：发现双重PRMT5-PRMT7抑制剂
- 作者：David Smil;∥;Mohammad S. Eram;∥;Fengling Li;Steven Kennedy;MagdalenaM. Szewczyk;Peter J. Brown;Dalia Barsyte-Lovejoy;Cheryl H. Arrowsmith;Masoud Vedadi;Matthieu Schapira;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第4期
- PRMT5 PRMT7 inhibitor methyltransferases;
3.Discovery of Pyrazolopyrimidine Derivatives as NovelDual Inhibitors of BTK and PI3Kδ

机译：新型吡唑并嘧啶衍生物的发现BTK和PI3Kδ的双重抑制剂
- 作者：Brahmam Pujala;Anil K. Agarwal;Sandip Middya;Monali Banerjee;Arjun Surya;AnjanK. Nayak;Ashu Gupta;Sweta Khare;Rambabu Guguloth;Nitin A. Randive;Bharat U. Shinde;Anamika Thakur;Dhananjay I. Patel;Mohd. Raja;Michael J. Green;Jennifer Alfaro;Patricio Avila;Felipe Pérezde Arce;Ramona G. Almirez;Stacy Kanno;Sebastián Bernales;David T. Hung;Sarvajit Chakravarty;Emma McCullagh;KevinP. Quinn;Roopa Rai;Son M. Pham;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第12期
- BTK PI3K p110δ inhibitor B-cell BCR pyrazolopyrimidine;
4.Discovery and Structure Enabled Synthesis of 26-Diaminopyrimidin-4-oneIRAK4 Inhibitors

机译：发现和结构化合成26-Diaminopyrimidin-4-oneIRAK4抑制剂
- 作者：W. Michael Seganish;*;Thierry O. Fischmann;Brad Sherborne;Julius Matasi;Brian Lavey;WilliamT. McElroy;Deen Tulshian;James Tata;Christopher Sondey;Charles G. Garlisi;Kristine Devito;James Fossetta;Daniel Lundell;Xiaoda Niu
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第8期
- IRAK4 kinase inhibitor inflammation structure-based drug design;
5.Discovery of a Potent and Selective ROMK Inhibitorwith Pharmacokinetic Properties Suitable for Preclinical Evaluation

机译：发现有效和选择性的ROMK抑制剂具有适合临床前评估的药代动力学特性
- 作者：Shawn P. Walsh;*;Aurash Shahripour;Haifeng Tang;Nardos Teumelsan;Jessica Frie;Yuping Zhu;BirgitT. Priest;Andrew M. Swensen;Jessica Liu;Michael Margulis;Richard Visconti;Adam Weinglass;John P. Felix;Richard M. Brochu;Timothy Bailey;Brande Thomas-Fowlkes;Magdalena Alonso-Galicia;Xiaoyan Zhou;Lee-Yuh Pai;Aaron Corona;Caryn Hampton;Melba Hernandez;Ross Bentley;Jing Chen;Kashmira Shah;Joseph Metzger;Michael Forrest;Karen Owens;Vincent Tong;Sookhee Ha;Sophie Roy;Gregory J. Kaczorowski;Lihu Yang;Emma Parmee;Maria L. Garcia;Kathleen Sullivan;Alexander Pasternak
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第7期
- ROMK hypertension heart failure diuresis natriuresis;
6.Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamideScaffold

机译：基于5-氨基吡唑-4-羧酰胺的弓形虫和小球藻CDPK1的强效和选择性抑制剂脚手架
- 作者：Zhongsheng Zhang;KayodeK. Ojo;RamaSubbaRao Vidadala;Wenlin Huang;Jennifer A. Geiger;Suzanne Scheele;Ryan Choi;Molly C. Reid;Katelyn R. Keyloun;Kasey Rivas;Latha Kallur Siddaramaiah;Kenneth M. Comess;Kenneth P. Robinson;Philip J. Merta;Lemma Kifle;Wim G. J. Hol;Marilyn Parsons;Ethan A. Merritt;Dustin J. Maly;Christophe L. M. J. Verlinde;Wesley C. Van Voorhis;*;Erkang Fan;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第1期
- Toxoplasma gondii Cryptosporidium parvum calcium-dependent protein kinase-1 enzyme inhibitor selectivity;
7.Analogues of the Natural Product Sinefungin as Inhibitorsof EHMT1 and EHMT2

机译：天然产物新氟菌素作为抑制剂的类似物EHMT1和EHMT2
- 作者：Kanchan Devkota;Brian Lohse;Qing Liu;Ming-Wei Wang;Dan Stærk;Jens Berthelsen;*;∥;Rasmus Prætorius Clausen;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第4期
- Sinefungin methyltransferase inhibitors EHMT1 EHMT2;
8.Isomannide-Based Peptidomimetics as Inhibitors forHuman Tissue Kallikreins 5 and 7

机译：基于异甘露聚糖的拟肽作为抑制剂人组织激肽释放酶5和7
- 作者：JoceliaP. C. Oliveira;‡;Renato F. Freitas;‡;Leandro Silva de Melo;Thalita G. Barros;Jorge A. N. Santos;Maria A. Juliano;Sérgio Pinheiro;Michael Blaber;Luiz Juliano;Estela M. F. Muri;Luciano Puzer;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第2期
- Serine protease kallikrein peptidomimetics inhibitor molecular dynamics;
9.VU6010608 a Novel mGlu7 NAM from a Seriesof N-(2-(1H-124-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides

机译：VU6010608系列中的新型mGlu7 NAM-（2-（1H-124-三唑-1-基）-5-（三氟甲氧基）苯基）苯甲酰胺的合成
- 作者：CarsonW. Reed;∥;Kevin M. McGowan;∥;Paul K. Spearing;Branden J. Stansley;Hanna F. Roenfanz;Darren W. Engers;Alice L. Rodriguez;Eileen M. Engelberg;Vincent B. Luscombe;Matthew T. Loch;Daniel H. Remke;JerriM. Rook;Anna L. Blobaum;P. Jeffrey Conn;Colleen M. Niswender;*;Craig W. Lindsley;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2017年第12期
- negative allosteric modulator metabotropic glutamate receptor 7 long-term potentiation VU6010608;
10.Synthesis and Evaluation of Conjugates of Novel TLR7Inert Ligands as Self-Adjuvanting Immunopotentiators

机译：新型TLR7缀合物的合成与评价惰性配体作为自佐剂免疫增强剂
- 作者：Dong Gao;Yu Liu;Yuwen Diao;Ningning Gao;Zhulin Wang;Wenqi Jiang;*;Guangyi Jin;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第3期
- Toll-like receptor agonist, adenine derivative, immunostimulatory activity;
11.Treating Pain with Somatostatin Receptor Subtype 4 Agonists

机译：生长抑素受体亚型4激动剂治疗疼痛
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第2期
12.Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function

机译：基于硫醇的有效和选择性HDAC6抑制剂促进微管蛋白乙酰化和T调节细胞抑制功能。
- 作者：Mariana C. F. Segretti;Gian Paolo Vallerini;Camille Brochier;Brett Langley;Liqing Wang;Wayne W. Hancock;Alan P. Kozikowski;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第11期
- HDAC6-selective inhibitors mercaptoacetamides 8-aminoquinoline 1234-tetrahydroquinoline Treg;
13.Synthesis and Biological Evaluation of SophoridinolDerivatives as a Novel Family of Potential Anticancer Agents

机译：槐定酚的合成及生物评价作为潜在抗癌药物的新家族的衍生物
- 作者：Chongwen Bi;§;Caixia Zhang;§;Yinghong Li;Sheng Tang;Shenggang Wang;Rongguang Shao;Haigen Fu;Feng Su;*;Danqing Song;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第11期
- Sophoridine sophoridinol structure−activity relationship antiproliferative drug resistance;
14.Novel Hybrids of Natural Oridonin-Bearing NitrogenMustards as Potential Anticancer Drug Candidates

机译：天然含冬凌草甲素氮的新型杂种芥末作为潜在的抗癌药物候选者
- 作者：Shengtao Xu;Lingling Pei;Chengqian Wang;Yun-Kai Zhang;Dahong Li;Hequan Yao;Xiaoming Wu;Zhe-Sheng Chen;*;Yijun Sun;Jinyi Xu;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第7期
- Oridonin antiproliferative activities nitrogen mustards combination principle drug-resistant apoptosis;
15.Discovery of Clinical Candidate BMS-906024: A PotentPan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors

机译：BMS-906024临床候选者的发现：有力泛缺口抑制剂治疗白血病和实体瘤
- 作者：Ashvinikumar V. Gavai;*;Claude Quesnelle;Derek Norris;Wen-Ching Han;Patrice Gill;Weifang Shan;Aaron Balog;Ke Chen;Andrew Tebben;Richard Rampulla;Dauh-Rurng Wu;Yingru Zhang;Arvind Mathur;Ronald White;Anne Rose;Haiqing Wang;Zheng Yang;Asoka Ranasinghe;Celia D’Arienzo;Victor Guarino;Lan Xiao;Ching Su;Gerry Everlof;Vinod Arora;Ding Ren Shen;Mary Ellen Cvijic;Krista Menard;Mei-Li Wen;Jere Meredith;George Trainor;Louis J. Lombardo;Richard Olson;Phil S. Baran;John T. Hunt;Gregory D. Vite;Bruce S. Fischer;Richard A. Westhouse;Francis Y. Lee
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第5期
- Notch inhibitor γ-secretase inhibitor SAR triple-negative breast cancer T-acute lymphoblastic leukemia;
16.Cryptocaryol Structure–Activity RelationshipStudy of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4

机译：隐甲酚的结构-活性关系癌细胞的细胞毒性和稳定PDCD4能力的研究
- 作者：MichaelF. Cuccarese;†;Yanping Wang;†;Penny J. Beuning;*;George A. O’Doherty;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第5期
- PDCD4 PDCD4 stabilizer cryptocaryols cryptocaryol SAR;
17.Total Synthesis and Biological Studies of TMC-205and Analogues as Anticancer Agents and Activators of SV40 Promoter

机译：TMC-205的全合成及生物学研究和类似物作为SV40启动子的抗癌剂和激活剂
- 作者：Yang Gao;†;Sami Osman;†;Kazunori Koide;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第8期
- natural product indole TMC-205 simian virus 40 promoter firefly luciferase gene activation;
18.Treatment of Cancer with NAMPT Inhibitors

机译：NAMPT抑制剂治疗癌症
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第6期
19.Pyridopyrimidinone Derivatives as Potent and Selectivec-Jun N-Terminal Kinase (JNK) Inhibitors

机译：吡啶并嘧啶酮衍生物具有较强的选择性c-Jun N-末端激酶（JNK）抑制剂
- 作者：Ke Zheng;⊥;Chul Min Park;⊥;#;Sarah Iqbal;Pamela Hernandez;HaJeung Park;Philip V. LoGrasso;*;Yangbo Feng;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第4期
- JNK3 kinase inhibitor Parkinson’s disease (PD) pyridopyrimidinone mitochondrial dysfunction;
20.Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4HIV Entry and Reverse Transcriptase

机译：吡唑并哌啶类化合物具有CCR5 / CXCR4的双重抑制作用HIV进入和逆转录酶
- 作者：BryanD. Cox;Anthony R. Prosser;Yongnian Sun;Zhufang Li;Sangil Lee;Ming B. Huang;Vincent C. Bond;James P. Snyder;Mark Krystal;Lawrence J. Wilson;Dennis C. Liotta;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第7期
- HIV-1 chemokine receptors viral entry inhibitors non-nucleoside reverse transcriptase inhibitors multitarget drug discovery;
21.Desmethyl Macrolides: Synthesis and Evaluation of4-Desmethyl Telithromycin

机译：脱甲基大环内酯类化合物的合成与评价4-去甲基泰利霉素
- 作者：Ian Glassford;Miseon Lee;Bharat Wagh;Venkata Velvadapu;Tapas Paul;Gary Sandelin;Charles DeBrosse;Dorota Klepacki;MeaganC. Small;Alexander D. MacKerell Jr.;Rodrigo B. Andrade;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第9期
- Total synthesis ketolide antibiotics antibiotic resistance telithromycin molecular modeling desmethyl analogues;
22.Novel Naphthalimide Aminothiazoles as Potential MultitargetingAntimicrobial Agents

机译：新型萘二甲酰亚胺咪唑类化合物潜在的多目标抗菌剂
- 作者：Ying-Ying Chen;Lavanya Gopala;Rammohan R. Yadav Bheemanaboina;Han-Bo Liu;Yu Cheng;Rong-Xia Geng;Cheng-He Zhou;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2017年第12期
- Naphthalimide aminothiazole antibacterial MRSA DNA human serum albumin;
23.Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesisand Evaluation as a Chelator for Cu-64

机译：膦酸酯侧链武装的丙烯跨桥Cyclam：合成和评估作为Cu-64的螯合剂
- 作者：Nikunj Bhatt;Nisarg Soni;YeongSu Ha;Woonghee Lee;Darpan N. Pandya;Swarbhanu Sarkar;Jung Young Kim;Hochun Lee;Sun Hee Kim;Gwang Il An;Jeongsoo Yoo;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第11期
- Bifunctional chelator propylene cross bridge phosphonate pendant arms radiopharmaceuticals;
24.Fused Heterocyclic Compounds as Potent Indoleamine-23-dioxygenase1 Inhibitors

机译：稠合杂环化合物作为有效的吲哚胺-23-二加氧酶1抑制剂
- 作者：Subhankar Panda;§;Ashalata Roy;§;Suman Jyoti Deka;Vishal Trivedi;Debasis Manna;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第12期
25.Preparation and Activities of Macromolecule Conjugatesof the CCR5 Antagonist Maraviroc

机译：大分子缀合物的制备及活性CCR5对抗剂Maraviroc的作品
- 作者：Shigehiro Asano;Julia Gavrilyuk;DennisR. Burton;Carlos F. Barbas III;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第2期
- CCR5 antagonist Maraviroc chemically programmed antibody PEGylation;
26.Discovery and Biological Evaluation of Novel DualEGFR/c-Met Inhibitors

机译：新型双重抗体的发现和生物学评价EGFR / c-Met抑制剂
- 作者：Bálint Szokol;○;Pál Gyulavári;○;Ibolya Kurkó;Ferenc Baska;Csaba Szántai-Kis;Zoltán Greff;Zoltán Őrfi;István Peták;Kinga Pénzes;Robert Torka;Axel Ullrich;László Őrfi;Tibor Vántus;*;△;György Kéri;*;△
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第4期
- NSCLC EGFR c-Met kinase inhibitor acquired resistance;
27.In This Issue Volume 5 Issue 6

机译：在本期中第5卷第6期
- 作者：Janice Elaine Y. Silverman
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第6期
28.Thioester Bonds of Thiocoraline Can Be Replaced with NMe-Amide Bridges without Affecting Its DNA-Binding Properties

机译：可以用NMe-酰胺桥取代硫代邻氨基苯甲酸的硫酯键而不会影响其DNA结合特性
- 作者：Rubí Zamudio-Vázquez;Fernando Albericio;Judit Tulla-Puche;*;Keith R. Fox;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第1期
- Thiocoraline bisintercalator DNA binding antitumor DNase I footprinting fluorescence melting;
29.Optimization of 124-Triazolopyridinesas Inhibitorsof Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

机译：124-三唑并吡啶的优化作为抑制剂人11β-羟基类固醇脱氢酶1（11β-HSD-1）的合成
- 作者：Jun Li;*;LawrenceJ. Kennedy;Haixia Wang;JamesJ. Li;Steven J. Walker;Zhenqiu Hong;Stephen P. O’Connor;Akbar Nayeem;DanielM. Camac;Paul E. Morin;Steven Sheriff;Mengmeng Wang;Timothy Harper;Rajasree Golla;Ramakrishna Seethala;Thomas Harrity;RandolphP. Ponticiello;Nathan N. Morgan;Joseph R. Taylor;Rachel Zebo;DavidA. Gordon;Jeffrey A. Robl;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第7期
- Enzyme inhibitors human 11β-hydroxysteroid dehydrogenase-type 1 triazolopyridines;
30.Pyrimidinone Nicotinamide Mimetics as Selective Tankyraseand Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

机译：嘧啶酮烟酰胺模拟物作为选择性坦科聚合酶和Wnt途径抑制剂适合体内药理学
- 作者：Jeffrey W. Johannes;*;Lynsie Almeida;Bernard Barlaam;P. Ann Boriack-Sjodin;Robert Casella;Rosemary A. Croft;Allan P. Dishington;Lakshmaiah Gingipalli;Chungang Gu;Janet L. Hawkins;Jane L. Holmes;Tina Howard;Jian Huang;Stephanos Ioannidis;Steven Kazmirski;Michelle L. Lamb;Thomas M. McGuire;Jane E. Moore;Derek Ogg;Anil Patel;Kurt G. Pike;Timothy Pontz;Graeme R. Robb;Nancy Su;Haiyun Wang;Xiaoyun Wu;Hai-Jun Zhang;Yue Zhang;Xiaolan Zheng;Tao Wang
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第3期
- Wnt, oncogenesis, pharmacokinetics, Caco2, tankyrase, PARP;
31.Discovery of Highly Potent Dual CysLT1 andCysLT2 Antagonist

机译：发现高效的双重CysLT1和CysLT2拮抗剂
- 作者：Satoshi Itadani;*;Shinya Takahashi;Masaki Ima;Tetsuya Sekiguchi;Manabu Fujita;Yoshisuke Nakayama;Jun Takeuchi
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第11期
- Cysteinyl leukotrienes CysLT1 CysLT2 dual antagonist asthma;
32.3-Cyano-3-aza-β-aminoAcid Derivativesas Inhibitors of Human Cysteine Cathepsins

机译：3-氰基-3-氮杂-β-氨基酸衍生物作为人类半胱氨酸组织蛋白酶的抑制剂
- 作者：Janina Schmitz;§;Anna-Madeleine Beckmann;§;Adela Dudic;Tianwei Li;Robert Sellier;Ulrike Bartz;Michael Gütschow;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第10期
- Cysteine proteases human cathepsins β-amino acids nitrile inhibitors;
33.Simple Methods for Tracking Stem Cells with 64Cu-Labeled DOTA-hexadecyl-benzoate

机译：使用64Cu标签的DOTA-十六烷基苯甲酸酯追踪干细胞的简单方法
- 作者：Min Hwan Kim;Sang-Keun Woo;Kwang Il Kim;Tae Sup Lee;Chan Wha Kim;Joo Hyun Kang;Byung Il Kim;Sang Moo Lim;Kyo Chul Lee;*;Yong Jin Lee;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第5期
- Adipose-derived stem cells copper-64 hexadecyl benzoate radiotracer PET;
34.Synthesis and Pharmacologyof a Novel κ OpioidReceptor (KOR) Agonist with a 135-Trioxazatriquinane Skeleton

机译：合成与药理κ阿片类药物的制备具有135-三氧杂氮杂三喹烷骨架的受体（KOR）激动剂
- 作者：Shigeto Hirayama;Naohisa Wada;Toru Nemoto;Takashi Iwai;Hideaki Fujii;Hiroshi Nagase;*;†
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第8期
- Opioid analgesics phenethylamine structure;
35.New Hits as Antagonists of GPR103 Identified by HTS

机译：HTS鉴定为GPR103拮抗剂的新命中
- 作者：Anneli Nordqvist;Lisbeth Kristensson;Kjell E. Johansson;Krystle Isaksson da Silva;Tomas Fex;Christian Tyrchan;Anette Svensson Henriksson;Kristina Nilsson;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第5期
- G-protein coupled receptor high throughput screening appetite regulation SP9155 26RFa 43RFa GPCR;
36.Prostaglandin EP3 Receptor Antagonists May Provide Novel Treatment for Diabetes

机译：前列腺素EP3受体拮抗剂可能为糖尿病提供新的治疗方法
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第6期
37.Inhibitors of the Renal Outer Medullary Potassium Channel

机译：肾外延髓钾通道的抑制剂
- 作者：Benjamin Blass;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第8期
38.Covalent Inhibitors of the TEC Family of Kinases andTheir Methods of Use

机译：TEC激酶和蛋白家族的共价抑制剂他们的使用方法
- 作者：Benjamin E. Blass;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2018年第7期
39.Relative Binding Affinities of Integrin Antagonistsby Equilibrium Dialysis and Liquid Chromatography–Mass Spectrometry

机译：整联蛋白拮抗剂的相对结合亲和力平衡透析和液相色谱-质谱联用
- 作者：WilliamJ. Tipping;§;Nkazimulo Tshuma;James Adams;HarveyT. Haywood;James E. Rowedder;M. Jonathan Fray;Thomas McInally;Simon J. F. Macdonald;Neil J. Oldham;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第2期
- Idiopathic pulmonary fibrosis αvβ6 integrin equilibrium dialysis liquid chromatography−mass spectrometry;
40.Discovery of a Selective TRPM8 Antagonist with ClinicalEfficacy in Cold-Related Pain

机译：发现具有临床选择性TRPM8拮抗剂感冒相关疼痛的疗效
- 作者：Mark D. Andrews;Kerry af Forselles;Kevin Beaumont;Sébastien R. G. Galan;Paul A. Glossop;Mathilde Grenie;Alan Jessiman;Amy S. Kenyon;Graham Lunn;Graham Maw;Robert M. Owen;*;David C. Pryde;Dannielle Roberts;ThienDuc Tran
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第4期
- TRPM8 clinical tool hypothermia PF-05105679 thermoregulation TRP channel ion channel pain;
41.Exploration of Pharmacophore in Chrysosplenol C asActivator in Ventricular Myocyte Contraction

机译：菜籽油C的药理学探索心室肌细胞收缩激活剂
- 作者：Eeda Venkateswararao;Min-Jeong Son;Niti Sharma;Manoj Manickam;PullaReddy Boggu;Young Ho Kim;Sun-Hee Woo;Sang-Hun Jung;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第7期
- Chrysosplenol C positive inotrope myosin activation contractility;
42.Design and Synthesis of P2–P4 Macrocycles Containinga Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors

机译：含P2-P4大环的设计与合成独特的螺环脯氨酸：新型HCV NS3 / 4A抑制剂
- 作者：Francisco Velázquez;*;Mariappan Chelliah;Martin Clasby;Zhuyan Guo;John Howe;Randy Miller;Santhosh Neelamkavil;Unmesh Shah;Aileen Soriano;Yan Xia;Srikanth Venkatraman;Samuel Chackalamannil;Ian W. Davies
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第12期
- Hepatitis C HCV HCV NS3/4A antivirals MK-5172 MK-8831;
43.SAR Studies of Indole-5-propanoic Acid DerivativesTo Develop Novel GPR40 Agonists

机译：吲哚-5-丙酸衍生物的SAR研究开发新型GPR40激动剂
- 作者：Dong-Oh Yoon;∥;Xiaodi Zhao;∥;Dohyun Son;Jung Tae Han;Jaesook Yun;Dongyun Shin;Hyun-Ju Park;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2017年第12期
- GPR40 agonists indole-5-propanoic acid NFAT reporter assay glucose-stimulated insulin secretion (GSIS);
44.Novel 24-Diarylaminopyrimidine Analogues (DAAPalogues)Showing Potent c-Met/ALK Multikinase Inhibitory Activities

机译：新型24-二芳基氨基嘧啶类似物（DAAPalogues）显示有效的c-Met / ALK多激酶抑制活性
- 作者：Zhiqing Liu;∥;Jing Ai;∥;Xia Peng;Zilan Song;Kui Wu;Jing Zhang;Qizheng Yao;Yi Chen;Yinchun Ji;Yanhong Yang;Meiyu Geng;*;Ao Zhang;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第4期
- C1-Substituted-N3-benzazepine c-Met/ALK dual inhibitor structure repurposing 24-diarylaminopyrimidine analogues;
45.Enhanced Cytotoxicity through Conjugation of a ClickableLuminescent Re(I) Complex to a Cell-Penetrating Lipopeptide

机译：通过结合可点击的增强细胞毒性发光的Re（I）复合物穿透细胞的脂肽
- 作者：Anna Leonidova;Vanessa Pierroz;Luke A. Adams;Nicholas Barlow;Stefano Ferrari;Bim Graham;*;Gilles Gasser;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第7期
- Anticancer fluorescence microscopy medicinal organometallic chemistry peptide rhenium complexes;
46.Synthesis of Novel Tylophorine Derivatives and Evaluationof Their Anti-Inflammatory Activity

机译：新型酪氨酸衍生物的合成与评价的抗炎活性
- 作者：Ti Wen;*;Ziwen Wang;*;Xianyi Meng;Meng Wu;Yangguang Li;Xiaoli Wu;Liqing Zhao;Puyue Wang;Zhinan Yin;Jesse Li-Ling;Qingmin Wang;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第9期
- Tylophorines derivatives anti-inflammatory activity Foxp3 TNF-α;
47.Novel Indole-N-glucoside TA-1887 As a Sodium Glucose Cotransporter 2 Inhibitor for Treatment of Type 2 Diabetes

机译：新型吲哚-N-葡萄糖苷TA-1887作为钠葡萄糖共转运蛋白2抑制剂用于治疗2型糖尿病
- 作者：Sumihiro Nomura;*;Yasuo Yamamoto;Yosuke Matsumura;Kiyomi Ohba;Shigeki Sakamaki;Hirotaka Kimata;Keiko Nakayama;Chiaki Kuriyama;Yasuaki Matsushita;Kiichiro Ueta;Minoru Tsuda-Tsukimoto
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第1期
- Type 2 diabetes sodium glucose cotransporter 2 inhibitor urinary glucose excretion indole-N-glucoside TA-1887 antihyperglycemic effect;
48.N1-FluoroalkyltryptophanAnalogues: Synthesis and in vitro Study as PotentialSubstrates for Indoleamine 2,3-Dioxygenase

机译：N1-氟烷基色氨酸类似物：潜在的合成和体外研究吲哚胺2,3-二加氧酶的底物
- 作者：Jean Henrottin;*;Astrid Zervosen;Christian Lemaire;Frédéric Sapunaric;Sophie Laurent;Benoit Van den Eynde;Serge Goldman;Alain Plenevaux;André Luxen
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第3期
- Tryptophan, indoleamine 2,3-dioxygenase, kynurenine, 1-(2-fluoroethyl)-tryptophan, tryptophan 2,3-dioxygenase, positron emission tomography;
49.Crystal Structures of PI3Kα Complexed with PI103and Its Derivatives: New Directions for Inhibitors Design

机译：PI3Kα与PI103配合的晶体结构及其衍生物：抑制剂设计的新方向
- 作者：Yanlong Zhao;‡;Xi Zhang;‡;Yingyi Chen;‡;Shaoyong Lu;‡;Yuefeng Peng;‡;Xiang Wang;Chengliang Guo;Aiwu Zhou;Jingmiao Zhang;Yu Luo;QianCheng Shen;Jian Ding;Linghua Meng;*;Jian Zhang;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第2期
- PI3K PI103 crystal structure drug design cancer therapy;
50.Discovery of a Potent Class of PI3Kα Inhibitorswith Unique Binding Mode via Encoded Library Technology (ELT)

机译：发现有效的PI3Kα抑制剂通过编码库技术（ELT）具有独特的绑定模式
- 作者：Hongfang Yang;Patricia F. Medeiros;Kaushik Raha;Patricia Elkins;Kenneth E. Lind;Ruth Lehr;Nicholas D. Adams;Joelle L. Burgess;Stanley J. Schmidt;Steven D. Knight;Kurt R. Auger;Michael D. Schaber;G. Joseph Franklin;Yun Ding;Jennifer L. DeLorey;∞;PaoloA. Centrella;#;Sibongile Mataruse;∞;Steven R. Skinner;Matthew A. Clark;#;JohnW. Cuozzo;#;Ghotas Evindar;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第5期
- Encoded Library technology ELT PI3Kα p110α PI3K p110α (H1047R);
51.Dihydropyrrolo23-dpyrimidines:Selective Toll-Like Receptor 9 Antagonists from Scaffold MorphingEfforts

机译：二氢吡咯并23-d嘧啶：来自脚手架变形的选择性Toll-like受体9拮抗剂努力
- 作者：Manabu Watanabe;Mai Kasai;Hideyuki Tomizawa;Masamitsu Aoki;Kazuo Eiho;Yoshiaki Isobe;Shigehiro Asano;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第11期
- Toll-like receptor 9 sepsis autoimmune disease dihydropyrrolo23-dpyrimidine LLE;
52.Dual RXR Agonists and RAR Antagonists Based on theStilbene Retinoid Scaffold

机译：基于的双重RXR激动剂和RAR拮抗剂。二苯乙烯类视黄醇支架
- 作者：Claudio Martínez;Michele Lieb;Susana Álvarez;Fátima Rodríguez-Barrios;Rosana Álvarez;Harshal Khanwalkar;Hinrich Gronemeyer;*;Angel R. de Lera;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第5期
- Retinoid receptor subtypes agonists antagonists arotinoids transactivation molecular modeling;
53.Prokineticin Receptor Modulators May Potentially Treat Psychiatric and Neurological Disorders

机译：Prokineticin受体调节剂可能会治疗精神病和神经病
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第8期
54.Inhibition of Cathepsin K: A Novel and Promising Treatment for Osteoporosis

机译：组织蛋白酶K的抑制：骨质疏松的一种新的和有希望的治疗。
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第6期
55.ROR(GMMA)T Modulating Activity for the Treatment ofCancers

机译：ROR（GMMA）T调节活性治疗糖尿病癌症
- 作者：Robert B. Kargbo;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2018年第7期
56.Factors Influencing in Vivo Dispositionof Polymeric Micelles on Multiple Administrations

机译：影响体内处置的因素胶束对多种给药方式的影响
- 作者：Eri Hara;Motoki Ueda;Akira Makino;Isao Hara;Eiichi Ozeki;Shunsaku Kimura;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第8期
- Molecular imaging nanoparticle ABC phenomenon IgM pharmacokinetics block polymer;
57.Preparation of N-Phenyl-lactam Derivatives Capable of Stimulating Neurogenesis and Their Use in the Treatment of Neurological Disorders

机译：能够刺激神经发生的N-苯基-内酰胺衍生物的制备及其在治疗神经系统疾病中的应用
- 作者：Benjamin Blass;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第11期
58.Hybrid Dopamine Uptake Blocker–Serotonin ReleaserLigands: A New Twist on Transporter-Focused Therapeutics

机译：杂种多巴胺摄取阻滞剂-5-羟色胺释放剂配体：针对转运蛋白的治疗学的新突破
- 作者：Bruce E. Blough;*;Antonio Landavazo;John S. Partilla;MichaelH. Baumann;Ann M. Decker;Kevin M. Page;Richard B. Rothman;§
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第6期
- Dopamine uptake inhibitors serotonin releasers serotonin receptor cocaine methamphetamine;
59.In This Issue Volume 5 Issue 10

机译：在本期中第5卷第10期
- 作者：Janice Elaine Y. Silverman
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第10期
60.PNA-Based Multivalent Scaffolds Activate the DopamineD2 Receptor

机译：基于PNA的多价支架激活多巴胺D2受体
- 作者：AndrewV. Dix;Jennie L. Conroy;Kara M. George Rosenker;David R. Sibley;Daniel H. Appella;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第4期
- Peptide nucleic acid multivalent display dopamine D2 receptor self-assembly;
61.BRD4 Structure–Activity Relationships of DualPLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536

机译：BRD4对偶的结构-活性关系PLK1激酶/ BRD4溴结构域抑制剂BI-2536
- 作者：Lijia Chen;JeremyL. Yap;Makoto Yoshioka;Maryanna E. Lanning;Rachel N. Fountain;Mithun Raje;Jacob A. Scheenstra;Jeffrey W. Strovel;Steven Fletcher;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第7期
- Bromodomain BRD BET protein−protein interaction kinase BI-2536;
62.Correction to Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway

机译：校正蒽醌衍生物作为c-Met激酶的强抑制剂和细胞外信号通路
- 作者：Zhongjie Liang;Jing Ai;Xiao Ding;Xia Peng;Dengyou Zhang;Ruihan Zhang;Ying Wang;Fang Liu;Mingyue Zheng;Hualiang Jiang;Hong Liu;*;Meiyu Geng;*;Cheng Luo;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第2期
63.Optimizing the Physicochemical Properties of Raf/MEKInhibitors by Nitrogen Scanning

机译：优化Raf / MEK的理化特性氮扫描抑制剂
- 作者：Toshihiro Aoki;Ikumi Hyohdoh;Noriyuki Furuichi;Sawako Ozawa;Fumio Watanabe;Masayuki Matsushita;Masahiro Sakaitani;Kenji Morikami;Kenji Takanashi;Naoki Harada;Yasushi Tomii;Koji Shiraki;Kentaro Furumoto;Mitsuyasu Tabo;Kiyoshi Yoshinari;Kazutomo Ori;Yuko Aoki;Nobuo Shimma;Hitoshi Iikura;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第4期
- Nitrogen scan Raf MEK kinase inhibitor CH5126766 RO5126766;
64.PAR2 Modulators Derived from GB88

机译：源自GB88的PAR2调制器
- 作者：Mei-Kwan Yau;‡;Ligong Liu;‡;Jacky Y. Suen;Junxian Lim;Rink-Jan Lohman;Yuhong Jiang;Adam J. Cotterell;GrantD. Barry;Jeffrey Y. W. Mak;David A. Vesey;Robert C. Reid;David P. Fairlie;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第12期
- Protease activated receptor 2 (PAR2) antagonist agonist structure−activity relationship (SAR) inflammation;
65.Two Potent OXE-R Antagonists: Assignment of Stereochemistry

机译：两种有效的OXE-R拮抗剂：立体化学分配
- 作者：Pranav Patel;§;Chintam Nagendra Reddy;Vivek Gore;§;Shishir Chourey;Qiuji Ye;Yannick P. Ouedraogo;∥;Sylvie Gravel;WilliamS. Powell;Joshua Rokach;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第7期
- 5-Oxo-ETE eosinophil OXE receptor antagonist enantiomeric optical purity chiral auxiliary;
66.Novel Cyclic Biphalin Analoguewith Improved AntinociceptiveProperties

机译：新型环比索林类似物具有改善的抗伤害感受性质
- 作者：Adriano Mollica;*;Alfonso Carotenuto;*;Ettore Novellino;Antonio Limatola;Roberto Costante;Francesco Pinnen;Azzurra Stefanucci;Stefano Pieretti;Anna Borsodi;Reza Samavati;Ferenc Zador;Sándor Benyhe;Peg Davis;Frank Porreca;VictorJ. Hruby
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第9期
- Analgesics biphalin dimeric opioid peptides cyclic analogues;
67.Discovery of DS-1558: A Potent and Orally BioavailableGPR40 Agonist

机译：DS-1558的发现：有效且口服的生物利用度GPR40激动剂
- 作者：Rieko Takano;Masao Yoshida;Masahiro Inoue;Takeshi Honda;Ryutaro Nakashima;Koji Matsumoto;Tatsuya Yano;Tsuneaki Ogata;Nobuaki Watanabe;Masakazu Hirouchi;Tomoko Yoneyama;Shuichiro Ito;Narihiro Toda;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第3期
- GPR40, agonist, insulin secretagogue, diabetes, glucose lowering;
68.Design Synthesis and Osteogenic Activity of DaidzeinAnalogs on Human Mesenchymal Stem Cells

机译：大豆苷元的设计合成及成骨活性人间充质干细胞类似物
- 作者：Amy L. Strong;Quan Jiang;Qiang Zhang;Shilong Zheng;StephenM. Boue;Steven Elliott;Matthew E. Burow;Bruce A. Bunnell;*;Guangdi Wang;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第2期
- Daidzein analogs mesenchymal stem cells BMSCs osteogenesis;
69.Accessible Chiral Linker to Enhance Potency and Selectivityof Neuronal Nitric Oxide Synthase Inhibitors

机译：可访问的手性连接子以增强效能和选择性一氧化氮合酶抑制剂的合成
- 作者：Qing Jing;Huiying Li;Linda J. Roman;Pavel Martásek;Thomas L. Poulos;*;Richard B. Silverman;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第1期
- Nitric oxide nitric oxide synthase enzyme inhibition neurodegenerative diseases;
70.Aptamer-Facilitated Cryoprotection of Viruses

机译：适体促进病毒的低温保护
- 作者：Shahrokh M. Ghobadloo;Ana Gargaun;Rebecca Casselman;Darija Muharemagic;Maxim V. Berezovski;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第11期
- Aptamer quadramer vesicular stomatitis virus viral stabilizers cryoprotection;
71.SAR and Structural Analysis of Siderophore-ConjugatedMonocarbam Inhibitors of Pseudomonas aeruginosa PBP3

机译：SAR和铁载体共轭结构分析铜绿假单胞菌PBP3的Monocarbam抑制剂
- 作者：Kerry E. Murphy-Benenato;*;∥;Brian Dangel;⊥;Hajnalka E. Davis;Thomas F. Durand-Réville;*;AndrewD. Ferguson;Ning Gao;Haris Jahić;John P. Mueller;Erika L. Manyak;#;Olga Quiroga;Michael Rooney;Li Sha;Mark Sylvester;Frank Wu;Mark Zambrowski;∇;Shannon X. Zhao
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第5期
- Pseudomonas aeruginosa β-lactam penicillin binding protein siderophore monocarbam structure-guided design;
72.Modulators of the Cystic Fibrosis Transmembrane ConductanceRegulator Protein

机译：囊性纤维化跨膜电导的调节剂调节蛋白
- 作者：Robert B. Kargbo;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2018年第7期
73.Fused Morphlinopyrimidines and Methods of Use Thereof

机译：熔融吗啉嘧啶及其使用方法
- 作者：Benjamin Blass;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第8期
74.Chemical Compounds as Inhibitors of Kinase Activityfor the Treatment of Cancer and COPD

机译：化合物作为激酶活性的抑制剂用于治疗癌症和COPD
- 作者：Robert B. Kargbo;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2017年第12期
75.Identification of Novel Phenyl Butenonyl C-Glycosides with Ureidyl and Sulfonamidyl Moieties as AntimalarialAgents

机译：鉴定新的苯基丁烯酰基C-糖苷与脲基和磺酰胺基部分作为抗疟药代理商
- 作者：K. KumarG. Ramakrishna;Sarika Gunjan;Akhilesh Kumar Shukla;Venkata Reddy Pasam;Vishal M. Balaramnavar;Abhisheak Sharma;Swati Jaiswal;Jawahar Lal;Renu Tripathi;*;Anubhooti;Ravishankar Ramachandran;Rama Pati Tripathi;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第8期
- Antimalarial agent phenyl sulfonamides diarylureides Plasmodium falciparum;
76.Discovery of the Fibrinolysis Inhibitor AZD6564 Actingvia Interference of a Protein–Protein Interaction

机译：发现纤溶抑制剂AZD6564起作用通过蛋白质-蛋白质相互作用的干扰
- 作者：Leifeng Cheng;⊥;Daniel Pettersen;*;Bengt Ohlsson;Peter Schell;#;Michael Karle;Emma Evertsson;○;Sara Pahlén;Maria Jonforsen;Alleyn T. Plowright;Jonas Boström;Tomas Fex;Anders Thelin;Constanze Hilgendorf;Yafeng Xue;Göran Wahlund;Walter Lindberg;∇;Lars-Olof Larsson;David Gustafsson
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第5期
- Fibrinolysis plasminogen inhibitor protein−protein interaction isoxazolone tranexamic acid;
77.LpxC Inhibitors as Effective Therapy Against Multidrug Resistant Bacterial Infections

机译：LpxC抑制剂作为抗多药耐药细菌感染的有效疗法
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第11期
78.Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors

机译：有效的和口服有效的基于联噻唑的组蛋白脱乙酰基酶抑制剂
- 作者：Fei Chen;†;Hui Chai;†;Ming-Bo Su;†;Yang-Ming Zhang;Jia Li;*;Xin Xie;*;Fa-Jun Nan;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第6期
- Histone deacetylase inhibitors largazole bisthiazole;
79.Mitochondria-Localized Fluorescent BODIPY-PlatinumConjugate

机译：线粒体定位荧光BODIPY-白金共轭
- 作者：Tingting Sun;Xingang Guan;Min Zheng;*;Xiabin Jing;Zhigang Xie;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第4期
- BODIPY cisplatin mitochondria imaging;
80.Target (In)Validation: A Critical Sometimes UnheraldedRole of Modern Medicinal Chemistry

机译：目标（进入）验证：关键（有时未公开）现代药物化学的作用
- 作者：Ramzi F. Sweis;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第6期
- Target validation target invalidation proof-of-concept biomarkers inactive controls;
81.Discovery of Short Peptides Exhibiting High Potencyagainst Cryptococcus neoformans

机译：发现具有高效能的短肽对抗新型隐球菌
- 作者：Amit Mahindra;Nitin Bagra;Nishima Wangoo;ShabanaI. Khan;Melissa R. Jacob;Rahul Jain;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第4期
- Antifungal peptides microwave TEM C. neoformans arylation;
82.Dimeric Macrocyclic Antagonists of Inhibitor of ApoptosisProteins for the Treatment of Cancer

机译：细胞凋亡抑制剂的二聚大环拮抗剂。治疗癌症的蛋白质
- 作者：Yong Zhang;*;Benjamin A. Seigal;NicholasK. Terrett;Randy L. Talbott;Joseph Fargnoli;Joseph G. Naglich;Charu Chaudhry;Shana L. Posy;Ragini Vuppugalla;Georgia Cornelius;Ming Lei;Chunlei Wang;Yingru Zhang;Robert J. Schmidt;Donna D. Wei;Michael M. Miller;Martin P. Allen;Ling Li;Percy H. Carter;Gregory D. Vite;Robert M. Borzilleri
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第7期
- Inhibitor of apoptosis proteins (IAPs) dimeric macrocyclic antagonists cancer;
83.Gossypol with Hydrophobic Linear Esters Exhibits EnhancedAntitumor Activity as an Inhibitor of Antiapoptotic Proteins

机译：具有疏水性线性酯的棉酚展览会得到增强抗肿瘤活性作为抗凋亡蛋白的抑制剂
- 作者：Yuzhi Lu;Shuangchan Wu;Yuan Yue;Si He;Jun Li;Jun Tang;Wei Wang;*;Hai-Bing Zhou;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第12期
- Gossypol Schiff bases linear amino acid esters antiapoptotic proteins;
84.C-Terminal ResidueOptimization and FragmentMerging: Discovery of a Potent Peptide-Hybrid Inhibitor of DengueProtease

机译：C端残基优化和片段合并：发现登革热的强肽混合抑制剂蛋白酶
- 作者：Mira A.M. Behnam;Christoph Nitsche;Sérgio M. Vechi;Christian D. Klein;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第9期
- Dengue virus protease inhibitor peptide fragment merging;
85.Synthesis of a New Peptide–Coumarin Conjugate:A Potential Agent against Cryptococcosis

机译：新肽-香豆素结合物的合成：潜在的预防隐球菌病的药物
- 作者：Soraya Z. Ferreira;Hellem C. Carneiro;Hugo A. Lara;Rosemeire B. Alves;Jarbas M. Resende;Heloísa M. Oliveira;Luciana M. Silva;Daniel A. Santos;Rossimiriam P. Freitas;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2016年第3期
- Antimicrobial peptide, copper(I)-catalyzed azide−
- alkyne cycloaddition, coumarin, cryptococcosis, reactive oxygen species;
86.Diversity-Oriented Synthesis Yields a New Drug Leadfor Treatment of Chagas Disease

机译：面向多样性的合成产生了新的药物线索恰加斯病的治疗
- 作者：Sivaraman Dandapani;*;Andrew R. Germain;Ivan Jewett;Sebastian le Quement;Jean-Charles Marie;Giovanni Muncipinto;JeremyR. Duvall;Leigh C. Carmody;Jose R. Perez;Juan C. Engel;Jiri Gut;Danielle Kellar;Jair Lage Siqueira-Neto;James H. McKerrow;Marcel Kaiser;Ana Rodriguez;MichelleA. Palmer;Michael Foley;Stuart L. Schreiber;Benito Munoz
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第2期
- Trypanosoma cruzi diversity-oriented synthesis Chagas disease neglected disease high-throughput screening phenotypic assay infectious disease Molecular Libraries Probe Production Centers Network;
87.Computation-Guided Discovery of Influenza EndonucleaseInhibitors

机译：计算指导的流感核酸内切酶发现抑制剂类
- 作者：Eric Chen;§;RobertV. Swift;§;Nazilla Alderson;VictoriaA. Feher;Gen-Sheng Feng;Rommie E. Amaro;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第1期
- Antiviral influenza A endonuclease pharmacophore virtual screening;
88.Benzimidazoles: Novel Mycobacterial Gyrase Inhibitorsfrom Scaffold Morphing

机译：苯并咪唑：新型分枝杆菌促旋酶抑制剂从脚手架变形
- 作者：Shahul Hameed P;*;Anandkumar Raichurkar;Prashanti Madhavapeddi;Sreenivasaiah Menasinakai;Sreevalli Sharma;Parvinder Kaur;Radha Nandishaiah;Vijender Panduga;Jitendar Reddy;Vasan K. Sambandamurthy;D. Sriram;‡
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第7期
- Tuberculosis type II topoisomerases DNA gyrase NBTIs aminopiperidines benzimidazoles;
89.Discovery of a Potentand Selective DGAT1 Inhibitorwith a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

机译：发现有力和选择性DGAT1抑制剂与哌啶基-氧基-环己烷羧酸部分
- 作者：Shuwen He;*;Qingmei Hong;Zhong Lai;David X. Yang;Pauline C. Ting;Jeffrey T. Kuethe;TimothyA. Cernak;Kevin D. Dykstra;Donald M. Sperbeck;Zhicai Wu;Yang Yu;Ginger X. Yang;Tianying Jian;Jian Liu;Deodial Guiadeen;Arto D. Krikorian;Lisa M. Sonatore;Judyann Wiltsie;Jinqi Liu;Judith N. Gorski;Christine C. Chung;Jack T. Gibson;JeanMarie Lisnock;Jianying Xiao;Michael Wolff;Sharon X. Tong;Maria Madeira;Bindhu V. Karanam;Dong-Ming Shen;James M. Balkovec;Shirly Pinto;Ravi P. Nargund;RobertJ. DeVita
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第10期
- DGAT1 inhibitor benzimidazole ACAT1 A2A receptor cyclohexanecarboxylic acid lipid tolerance test epimerization metabolite Ames test skin;
90.Synthesis in Vitro CovalentBinding Evaluation andMetabolism of 14C-Labeled Inhibitors of 11β-HSD1

机译：体外共价合成绑定评估以及14β-标记的11β-HSD1抑制剂的代谢
- 作者：Daqing Sun;*;Qiuping Ye;*;Xuelei Yan;Yosup Rew;Peter Fan;Xiao He;Min Jiang;DustinL. McMinn;Mario Monshouwer;Hua Tu;Jay P. Powers
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第11期
- 11β-HSD1 11β-HSD2 diabetes metabolic syndrome hydroxysteroid dehydrogenase arylsulfonylpiperazine diarylsulfone 44-disubstituted cyclohexylbenzamides radiolabeled inhibitor covalent protein binding bioactiviation reactive metabolite;
91.Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer Obesity and Liver Related Disorders

机译：脂肪酸合酶（FASN）抑制剂可潜在治疗癌症肥胖和肝脏相关疾病
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第8期
92.N-(3-Ethynyl-24-difluorophenyl)sulfonamideDerivatives as Selective Raf Inhibitors

机译：N-（3-乙炔基-24-二氟苯基）磺酰胺衍生物作为选择性Raf抑制剂
- 作者：Yingjun Li;Huimin Cheng;Zhang Zhang;Xiaoxi Zhuang;Jinfeng Luo;Huoyou Long;Yang Zhou;Yong Xu;Rana Taghipouran;Dan Li;Adam Patterson;Jeff Smaill;Zhengchao Tu;Donghai Wu;Xiaomei Ren;*;Ke Ding;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第5期
- B-Raf colon cancer melanoma kinase inhibitor targeted therapy;
93.Ubiquitin-Specific Inhibitors for the Treatment ofCancers Autoimmune and Infectious Diseases

机译：泛素特异性抑制剂治疗癌症自身免疫和传染病
- 作者：Robert B. Kargbo;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2017年第12期
94.Optimization of Rutaecarpineas ABCA1 Up-Regulatorfor Treating Atherosclerosis

机译：Rutaecarpine的优化作为ABCA1上调器治疗动脉粥样硬化
- 作者：Yongzhen Li;Tingting Feng;Peng Liu;Chang Liu;Xiao Wang;Dongsheng Li;Ni Li;Minghua Chen;Yanni Xu;*;Shuyi Si;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第8期
- Rutaecarpine ABCA1 RCT atherosclerosis;
95.Therapeutic Potential of GPR120 Agonists for the Treatment of Type 2 Diabetes

机译：GPR120激动剂对2型糖尿病的治疗潜力
- 作者：Ahmed F. Abdel-Magid;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第11期
96.Development of Novel Benzomorpholine Class of DiacylglycerolAcyltransferase I Inhibitors

机译：新型苯并吗啉类二酰基甘油的研制酰基转移酶I抑制剂
- 作者：Gang Zhou;*;Nicolas Zorn;Pauline Ting;Robert Aslanian;Mingxiang Lin;John Cook;Jean Lachowicz;Albert Lin;Michelle Smith;Joyce Hwa;Margaret van Heek;Scott Walker
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第5期
- DGAT1 diacylglycerol acyltransferase inhibitor benzomorpholine postprandial triglyceridemia (PPTG);
97.Retraction of Novel 2-Aminobenzamidesas Potential Orally Active Antithrombotic Agents

机译：收回 Novel 2-Aminobenzamides作为潜在的口服抗血栓药
- 作者：Amit Verma;Rajani Giridhar;Ashish Kanhed;Anshuman Sinha;Pratik Modh;Mange R. Yadav;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第2期
98.Toward the Developmentof Bivalent Ligand Probes ofCannabinoid CB1 and Orexin OX1 Receptor Heterodimers

机译：走向发展二价配体探针的制备大麻素CB1和Orexin OX1受体异二聚体
- 作者：DavidA. Perrey;Brian P. Gilmour;Brian F. Thomas;Yanan Zhang;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2014年第6期
- Cannabinoid orexin heterodimer bivalent ligands;
99.Using Tumor Explants for Imaging Mass SpectrometryVisualization of Unlabeled Peptides and Small Molecules

机译：使用肿瘤外植体进行质谱成像可视化未标记的肽和小分子
- 作者：BrianP. David;Oleksii Dubrovskyi;Thomas E. Speltz;Jeremy J. Wolff;Jonna Frasor;Laura M. Sanchez;Terry W. Moore;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2018年第7期
- Cancer cell penetration explants MALDI-TOF mass spectrometry;
100.Discovery of a Novel Series of Thienopyrimidine asHighly Potent and Selective PI3K Inhibitors

机译：发现新系列的噻吩并嘧啶高活性和选择性PI3K抑制剂
- 作者：Fangbin Han;†;Songwen Lin;†;Peng Liu;Xiujie Liu;Jing Tao;Xiaobing Deng;Chongqin Yi;Heng Xu;*
- 期刊名称：《ACS Medicinal Chemistry Letters》 | 2015年第4期
- thienopyrimidines phosphoinositide 3-kinase mammalian target of rapamycin dual inhibitors selective PI3K inhibitors;