Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy

摘要

Scheme of exogenous MF-boosted Fenton reaction and responsive magnetic resonance imaging (MRI) using HCSVs, TEM images of HCSVs treated with the circularly polarized magnetic field (MF, 2 Hz) for various time-periods. Experiments were repeated three times. Relative concentration change of Ferrous ions tested by the ferrous probe,  = 3 independent samples. Data are shown as means ± s.d. Ferrostatin-1 rescued TRAMP-C1 cells treated with HCSVs with/without MF,  = 3 independent samples.  = 0.017 Flow cytometry assay of calreticulin (CRT) exposure on the surface of TRAMP-C1 after various treatment. Relative quantification of Flow cytometry assay of CRT exposure.  = 3 independent samples. Data are shown as means ± s.d. p t-test. Source data are provided as a file.