Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy

摘要

After overcoming pathophysiological barriers, multifunctional nanoparticles composed of ICD inducers and immune inhibitors induce tumor cell death via immunogenic pathways. The DAMPs released by dying cells play a crucial role in modulating the immunogenicity of the tumor microenvironment, including promoting the recruitment of APCs through tumor cell-derived secreted ATP and HMGB1 and facilitating DC maturation. Subsequently, activated DCs prime T cells, enabling CTLs to kill tumor cells via IFN-γ-dependent mechanisms.