methods of reversing or preventing the resistance of a cell to a death receptor agonist, of screening a cell for a biomarker of resistance to a death receptor agonist, of monitoring resistance to a death receptor agonist in an individual , to selectively induce apoptosis in a target cell expressing a death receptor, to treat an individual with cancer, to treat an individual with an inflammatory or autoimmune disease, to block the binding of the card-containing protein to a death receptor in a cell, to block the association of an iap with the death receptor and to screen a modulator of a protein containing card, composition, isolated nucleic acid, vector, cell, and isolated polypeptide

摘要

METHODS OF REVERSING OR PREVENTING A CELL RESISTANCE TO A DEATH RECEIVER AGONIST, TRIATING A CELL AS A RESISTANCE BIOMARKER, MONITORING A RECEIVER MIST RESISTANT TO A RECEIVER MIST RESISTANT , SELECTIVELY INDUCING APOPTOSIS IN A TARGET CELL EXPRESSING A DEATH RECEIVER, TREATING AN INDIVIDUAL WITH CANCER, DEALING WITH AN INFLAMMATORY OR AUTOIMMUNE DISEASE, BLOCKING THE CALL OF THE PROTEIN MENTAL CELL A CELL, BLOCKING THE ASSOCIATION OF AN IAP WITH THE RECEIVER OF DEATH AND CREATING A MODULATOR OF A PROTEIN CONTAINING CARD, COMPOSITION, INSULATED NUCLEIC ACID, VECTOR, CELL, AND ISOLATED POLYPEPTIDE. A method of reversing or preventing resistance of target cells to a death receptor agonist is provided in this report. Screening methods for biomarker resistance and for monitoring the resistance of death receptor agonists are also provided. Also provided are methods of selectively inducing apoptosis in a target cell in the case of an individual with cancer, autoimmune or inflammatory diseases comprising administering the compositions provided in this report. Further provided are compositions comprising agents that modulate CARD-containing proteins.