isolated antigen binding region that is specific for cd38, isolated antibody or a functional fragment thereof that is specific for cd38, isolated antibody or a functional fragment thereof, isolated immunoglobulin, heavy chain variable of an isolated antigen binding region, variable light chain from an isolated antigen binding region, isolated nucleic acid sequence, nucleic acid sequence encoding a variable heavy chain from an isolated antigen binding region, nucleic acid sequence, vector, isolated cell, pharmaceutical composition, use of the pharmaceutical composition, method of inducing specific death of cd38-expressing tumor cells, method of detecting specific death of cd38-expressing tumor cells, method of detecting the presence of cd38 in a minipore source tissue or cell , cd38 detection method in a cd3-expressing erythrocyte 8 and diagnostic composition

摘要

ISLAND OF ANTIGEN INSULATED CONNECTION THAT IS SPECIFICALLY TO CD38, ISOLATED ANTIBODY OR A FUNCTIONAL FRAGMENT OF THE SAME THAT IS SPECIFIC TO CD38, ISOLATED ANTIBODY OR TOGETHER ISOLATED, ISOLATED CLEARLY ISOLATED OF ISOLATED VARIABLE LIGHT CHAIN OF AN ISOLATED ANTIGEN CONNECTION, NUCLEIC ACID SEQUENCE, NUCLEIC ACID SEQUENCE, CODING A VARIABLE ISOLATED NUCLEAR CONNECTION REGION, USE OF PHARMACEUTICAL COMPOSITION, METHOD OF INDUCING SPECIFIC TUMOR CELLS EXPRESSING CD38, METHOD OF DETECTION OF TUMOR CELLS EXPRESSING CD38 OR TYPE CELL METHOD MINIPORCO, CD38 DETECTION METHOD IN AN ERYTHROCYTE EXPRESSING CD38 AND COMPOSITION The present invention provides novel antibodies and methods for using antigen-binding binding regions and antibodies and functional fragments containing such antigen binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods benefit from the newly discovered antibodies and the surprising properties of such antibodies, such as the ability to bind to minigrain source CD38 and the ability to induce, by crosslinking, a specific killing of CD38 expressing cells. Such antibodies, as well as novel methods for using such antibodies, may be used for the treatment, for example, of hematological malignancies such as multiple myeloma.