Purified antibody, methods for selectively inducing cell death in target cells and for treating an individual with cancer and having an inflammatory disease or autoimmune disease, methods for inhibiting target cell proliferation, for treating an individual with an apoptosis-related disease, for producing a humanized antibody and to increase nfkb levels in a cell, composition, use of an antibody, isolated nucleic acid, vector, cultured cell, purified polypeptide, and commercial kit for inducing apoptosis.

摘要

"PURIFIED ANTIBODY, METHODS FOR SELECTIVELY INDUCING CELL DEATH IN TARGET CELLS AND FOR TREATING AN INDIVIDUAL WITH CANCER AND WHICH HAVE AN INFLAMMATORY DISEASE OR AUTOIMMUNE DISEASE, PROCEDURES FOR IMBIRING CELL DIVERSION FOR A CELL RELATIONSHIPS PRODUCE A HUMAN ANTIBODY AND TO INCREASE NFkB LEVELS IN A CELL, COMPOSITION, USE OF AN ANTIBODY, ISOLATED NUCLEIC ACID, VECTOR, CULTIVATED CELL, AND PURIFIED POLYPEPTIDIA, FOR COMMERCIAL INDUCT KIT. An antibody of the invention interacts with human DR5 to produce downstream receptor agonistic and antagonistic effects including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies were elucidated, and vectors and cells containing and expressing these sequences were generated. Methods and uses for antibodies, including treatment of apoptosis-related disease and treatment of unregulated cell growth, are detailed.