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中国医药导刊

中国医药导刊

CSTPCD

Chinese Journal of Medical Guide
本刊是由国家食品药品管理局主管、国家食品药品管理局信息中心主办的国内外公开发行的医药科技核心期刊。读者对象为国内临床医药工作者。由国内著名心血管专家胡大一担任总编，国内100多名著名临床医药专家、药品审评和评价专家参与编审。本刊紧密结合临床实际，突出先导性、实用性和时效性，是临床医药工作者的重要参考文献，也是医药生产及营销企业了解我国临床信息的重要窗口。
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  • 被引量：44839
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  • 国内刊号/CN：11-4395/R
    国际刊号/ISSN：1009-0959
  • 发行周期：月刊
    邮发代号：2-492
  • 主管单位：国家食品药品监督管理局
    主办单位：国家食品药品监督管理局信息中心
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中国医药导刊 >2023年第8期

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  • 摘要：Objective: To analyze the effect of health examination combined with peripheral blood glucose monitoring in screening of diabetes mellitus.Methods:150 cases of diabetic patients and 50 cases of healthy control personnel as the research object,diabetic group and healthy control group received health examination for the measurement of glycated hemoglobin (HbAlc) and peripheral blood glucose, fasting blood glucose (FPG) and meal after 2h blood glucose (2hPG). Compare the levels of HbAlc, FPG and 2hPG in diabetic patients and healthy controls, and analyze the value of health examination combined with peripheral blood glucose testing in screening for diabetes. Results:The levels of FPG, 2hPG and HbAlc in diabetic foot patients were higher than those in healthy control group. The differences of FPG,2hPG and HbAlc levels between the two groups were statistically significant (P<0.05). According to the sensitivity of FPG,2hPG, HbAlc index for screening of diabetes was 99.3%, the specificity was 94.2%, the accuracy rate was 98.5%. Conclusion:The detection of FPG, 2hPG and HbAlc can improve the rate of diabetes screening, and the results are accurate and reliable.%目的：分析健康体检联合末梢血糖监测在筛查糖尿病中的作用。方法：选择150例糖尿病患者和50例健康体检对照人员为研究对象，糖尿病组和健康对照组接受健康体检测量糖化血红蛋白（HbAlc）和末梢血糖检测空腹血糖（FPG）和餐后2h血糖（2hPG）。对比糖尿病患者和健康对照组的HbAlc、FPG、2hPG水平，分析健康体检联合末梢血糖检测在筛查糖尿病中的价值。结果：糖尿病足患者的FPG、2hPG、HbAlc水平高于健康对照组，两组患者的FPG、2hPG、HbAlc水平差异有统计学意义（P＜0.05）。根据FPG、2hPG、HbAlc指标筛查糖尿病的灵敏度为99.3%、特异度为94.2%，准确率为98.5%。结论：健康体检联合末梢血糖检测测定FPG、2hPG、HbAlc可提高糖尿病筛查率，筛查结果准确可靠。
  • 摘要：目的：探讨缺血性脑卒中患者颈动脉粥样硬化斑块与H型高血压的相关性。方法：选取2012年10月～2014年10月期间，我院收治的缺血性脑卒中患者临床资料162份，分为实验组和对照组。实验组为有颈动脉粥样硬化斑块的缺血性脑卒中患者101例，对照组为没有颈动脉粥样硬化斑块的缺血性脑卒中患者61例。采用酶联免疫法对患者的同型半胱氨酸进行检测，并根据检测结果和高血压史将所有的患者分为四种类型，A类为H型高血压患者，B类为普通高血压组患者，C类为高同型半胱氨酸患者，D类为高血压和同型半胱氨酸都正常的患者，分别对实验组和对照组进行四种类型的检测，将两组检测结果进行比较，分析缺血性脑卒中患者颈动脉粥样硬化斑块与H型高血压的相关性。结果：实验组患者在年龄、吸烟史、高血压史、低密度脂蛋白与对照组患者想比较，有显著差异P＜0.05，具有统计学意义；实验组患者和对照组患者中四种类型患者有明显的差异，P＜0.05，具有统计学意义，且实验组患者中，A类H型高血压患者发生率最高，其次是B类普通高血压组患者，再者就是C类高同型半胱氨酸患者，最后是D类高血压和同型半胱氨酸都正常的患者。结论：H型高血压缺血性脑卒中患者发生颈动脉粥样硬化斑块的概率最高。%Objective: To explore the ischemic stroke patients with carotid atherosclerotic plaque and H the correlation of high blood pressure.Methods: Selection during October 2012 to October 2012, our hospital clinical data of 162 patients with ischemic stroke, divided into the experimental group and the control group, experimental group is in the form of carotid atherosclerotic plaques, 101 cases of ischemic cerebral apoplexy patients and control group with no carotid atherosclerotic plaque of 61 cases of ischemic cerebral apoplexy patients, using enzyme-linked immunoassay of homocysteine in patients with testing, and according to the test results, A history of high blood pressure, all patients can be divided into four types, A class of H type patients with high blood pressure, class B for ordinary high blood pressure patients, class C for patients with high homocysteine, class D for patients with hypertension and normal homocysteine, respectively to four types of test group and the control group, compared two groups of test results, analysis of ischemic stroke in patients with carotid atherosclerosis plaque with H the correlation of high blood pressure. Results: Experimental group patients for age, smoking history, history of high blood pressure, low density lipoprotein cholesterol (LDL-C) patients want to compare with control group, there were significant differences (P<0.05, statistically significant; Four types of experimental group patients and the control group patients have obvious differences, P<0.05, statistically significant, and the experimental group patients, class A H the highest incidence of hypertension patients, followed by the class B ordinary high blood pressure patients, moreover is C in patients with high homocysteine, finally the class D hypertension patients and normal homocysteine. Conclusion:H high blood pressure in patients with ischemic stroke of carotid atherosclerosis plaque has the highest probability.
  • 摘要：Objective: To investigate and analyze the knowledge level and health education needs of family members of children with fever.Methods:150 cases of children with fever as the research object,30 cases of primary school and the following qualifications,50 cases of junior high school education,50 cases of high school education, college and above 20 cases.To the families of children with fever knowledge questionnaire,health education needs questionnaire survey,analysis of the family members of the children to grasp the knowledge level of fever and health education for health needs.Results:The families of the children with fever fever related knowledge level is low, visit the families of children with fever related knowledge level is slightly higher than that of newly diagnosed children with their families.College degree or above, the families of children with fever and health education needs the highest proportion of health education,primary school and the following degree of fever patients with the lowest proportion of health education needs. Fever in children with relative knowledge mainly comes from newspapers, magazines, books (34.7%) and radio and television (26.0%), the accumulation of the disease is self, medical personnel and network get fever knowledge than the number was 10%, 18.7%, 10.6%. Conclusion:The families of the children with fever related knowledge level is generally low,the families of children with different levels of education have different needs for health education, nursing staff should according to the characteristics of the families of the children take a diversified, for health education measures to meet the needs of different types of families of children, improve the knowledge level of related to fever.%目的：调查及分析发热患儿家属相关知识水平与健康教育需求。方法：以150例发热患儿家属为研究对象，小学及以下学历30例、初中学历50例、高中学历50例、专科及以上学历20例。向患儿家属发放发热知识调查表、发热健康教育需求问卷调查表，分析患儿家属掌握发热知识水平及对发热健康教育的需求。结果：发热患儿家属的发热相关知识水平较低，复诊患儿家属的发热相关知识水平略高于初诊患儿家属。专科及以上学历发热患儿家属对发热健康教育需求人数比例最高，小学及以下学历发热患者家属对健康教育需求人数比例最低。发热患儿家属相关知识主要源于报纸、杂志、书籍（34.7%）和广播电视（26.0%），经疾病自我积累、医护人员及网络获取发热知识人数比分别为10%、18.7%、10.6%。结论：发热患儿家属相关知识水平普遍偏低，不同学历水平患儿家属对健康教育需求不同，护理人员应根据患儿家属的特点采取多元化、针对性的健康教育措施，满足不同类型患儿家属的需求，提高发热相关知识水平。
  • 摘要：Objective: To analyze the effect of laparoscopic surgery on the length of stay and the complications after laparoscopic surgery in patients with gastric and duodenal perforation complicated with diabetes. Methods:Collect analysis 2015 March 2016 years 3 months in our hospital from gastroduodenal perforation patients complicated with diabetes in 60 cases as the object of study,were randomly divided into experimental group and control group,the control group with conventional open repair in the treatment,the experimental group used laparoscopic surgery, compared two groups of clinical effect.Results:Experimental complications hair group rate,hospitalization time (13.33%),(5.33±2.17) days was significantly less than that of the control group (30.0%), (908±2.66) d, the experimental group and control group two groups preoperative blood glucose values were not significantly different,no statistical significance (P>0.05).Postoperative experimental group,the levels of blood glucose values (901±1.67) mmol/L glucose control was significantly better than the control group,difference has statistical significance (P<0.05). Conclusion:Gastric and duodenal perforation patients complicated with diabetes underwent laparoscopic surgery can shorten the time of hospitalization, reduce the postoperative complications, is a safe and effective surgical method.%目的：分析胃十二指肠穿孔并发糖尿病患者行腹腔镜手术治疗对其住院时间与术后并发症的影响。方法：收集2015年3月～2016年3月我院收治的胃十二指肠穿孔并发糖尿病患者60例作为研究对象，随机分为实验组和对照组，对照组采用传统开腹修补术治疗，实验组使用腹腔镜手术治疗，比较两组临床效果。结果：实验并发症发组生率、住院时间（13.33%）、（5.33±2.17）d明显少于对照组（30.0%）、（9.08±2.66）d，实验组与对照组两组术前血糖值差异不显著，无统计学意义（P＞0.05），术后实验组血糖值（9.01±1.67）mmol/L血糖控制情况明显优于对照组，差异显著具有统计学意义（P＜0.05）。结论：胃十二指肠穿孔并发糖尿病患者行腹腔镜手术治疗能够缩短住院时间、减少术后并发症，是一种安全有效的手术方式。
  • 摘要：目的：观察间苯三酚在人工流产术中的临床效果。方法：将2014年3月6日～2015年5月16日在我院门诊要求行人工流产术的患者100例作为研究对象，随机分成两组，观察组和对照组分别50例，观察组于人工流产术前15min静脉注射间苯三酚80mg，对照组为常规行人工流产术。比较两组宫颈软化程度、手术时间、术中出血量、镇痛疗效、不良反应等。结果：镇痛有效率、宫颈软化程度比较，观察组显著优于对照组，差异有显著性(P＜0.05)。手术时间、不良反应发生率比较，观察组显著低于对照组，差异有显著性(P＜0.05)。另外，观察组患者的术中出血量略低于对照组，但是两组比较，差异无统计学意义(P＞0.05)。结论：间苯三酚用于人工流产术中效果显著，其镇痛效果好、有效软化宫颈、手术时间缩短、不良反应发生率低，费用低，安全有效。%Objective: To observe the clinical effect of phloroglucinol in artificial abortion.Methods: The patients with 100 cases of abortion as an object of study. Methods: The patients with 100 cases of abortion as an object of study from March 6, 2014 to May 16, 2015 in our hospital, Were randomly divided into two groups, the observation group and the control group of 50 patients were observed between the groups in the abortion 15 min before intravenous phloroglucinol 80 mg, the control group routine abortion. Comparison of two cervical softening degree, operative time, blood loss, analgesic efficacy, adverse reactions. Results: Analgesic effectiveness, the degree of softening of the cervix compared with the observation group was significantly better than the control group, the difference was significant (P<0.05). Operative time, incidence of adverse reactions compared with the observation group was significantly lower than the control group, the difference was significant (P<0.05). In addition, the observation group blood loss was slightly lower than in the control group of patients, but the two groups, the difference was not statistically significant (P>0.05).Conclusion: Phloroglucinol induced abortion results are obvious, good analgesic effect, effectively soften the cervix, operation time, low incidence of adverse reactions, low cost, safe and effective.
  • 摘要：目的：分析胎儿畸形功能诊断结果，评估胎儿畸形发生情况。方法：回顾性分析217例诊断为胎儿宫内畸形产妇的影像学检查结果资料，包括胎儿畸形诊断结果、胎儿畸形诊断时间、羊水情况、孕妇年龄等。结果：畸形类型以神经系统畸形（37.8%）、心脏畸形（20.3%）、泌尿系统畸形（18.9%）居多，畸形胎儿检出时间主要在孕14～27周（75.1%）和孕28周（22.6%）以后，孕妇年龄在25～34岁发生胎儿畸形率最高（77.0%）。羊水过多和羊水过少发生率分别为6.5%、2.3%。结论：胎儿畸形主要为神经系统畸形、心脏畸形、泌尿系统畸形，胎儿畸形与产妇年龄关系密切，产妇应在孕28周前行产检，及时检出畸形胎儿。%Objective: To analyze the diagnostic results of fetal malformation and assess the occurrence of fetal abnormalities.Methods:A retrospective analysis of 217 cases diagnosed as fetal intrauterine fetal malformation in maternal imaging results data,including fetal malformation diagnosis results,fetal malformation diagnosis time,amniotic fluid situation,pregnant women's age, etc.. Results:Malformation type to nervous system malformations (37.8%) and heart malformations (20.3%), urinary system malformations (18.9%) majority, fetal malformation detection time mainly in pregnant 14-27 weeks (75.1%) and pregnancy 28 weeks (22.6%). The age of the pregnant woman in the 25 to 34 year old fetal malformation rate was the highest (77.0%). The incidence of too much amniotic fluid and amniotic fluid were 6.5% and 2.3% respectively. Conclusion:Fetal malformation is mainly nervous system abnormalities, cardiac malformations, urinary system abnormalities, fetal malformation and maternal age, maternal age should be 28 weeks before the birth of the inspection, timely detection of abnormal fetus.
  • 摘要：目的：分析中西医结合治疗更年期功能性子宫出血（功血）的临床效果。方法：选取秦皇岛市中医医院妇科符合入选标准的崩漏患者120例，单盲随机分为治疗组和对照组，每组60例，120例患者经宫腔镜诊查加之病理诊断后，分为两组，治疗组采用崩漏止血方加减联合屈螺酮炔雌醇片（优思明）治疗；对照组单纯口服优思明治疗，连续随访6个月，并记录复发时间、复发次数等情况。结果：治疗组的临床有效率为97.1%，对照组为81.4%；治疗组患者更年期功血复发率及复发次数低于对照组，复发时间长于对照组，两组患者治疗有效率、复发率、平均复发时间和复发次数差异有统计学意义（P＜0.05）治疗组和对照组的不良反应发生率分别为5.7%、4.3%，不良反应差异无统计学意义。结论：中西医结合可显著提高临床治疗更年期功血的疗效，且复发率低、安全性高。%Objective: To analyze the clinical effect of combining traditional Chinese and Western medicine treatment of climacteric dysfunctional uterine bleeding.Methods:In Qinhuangdao Hospital of Traditional Chinese Medicine of department of gynaecology conforms to the selected standard of 120 patients with uterine bleeding, single blinded and randomly divided into treatment group and control group, 60 cases in each group, 120 patients after hysteroscopic diagnosis and chattanooga pathological diagnosis, divided into two groups, treatment group with metrorrhagia and metrostaxis hemostasis decoction"plus yasmin treatment; according to the treatment group were treated with oral yasmin, continuous follow-up for 6 months, and record the recurrent time and the times.Results:Clinical treatment group, the rate was 97.1%, 81.4% in the control group. The treatment group patients with climacteric dysfunctional uterine bleeding recurrence rate and recurrence times lower than that of the control group, the recurrence time was longer than the control group, the two groups of patients with treatment rate, recurrence rate, mean recurrence time and recurrence frequency differences have statistical significance (P<0.05) in the treatment group and control group of adverse reaction incidence rate was 5.7% and 4.3%, respectively, the differences in the adverse reactions without significant.Conclusion:Combine traditional Chinese and Western medicine can significantly improve the efficacy of clinical treatment of climacteric dysfunctional uterine bleeding, and the recurrence rate is low, the safety is high. It is worthy of clinical application.
  • 摘要：Objective: To explore the application value of MeteoSpasmyl in the treatment of irritable bowel syndrome from the perspective of pharmacoeconomics.Methods:92 cases with diarrhea predominant irritable bowel syndrome were included and randomly divided into 2 groups.The observation group was treated with MeteoSpasmyl. The control group was treated with Dicetel.After 8 weeks, the efficacy and adverse reactions of 2 groups were compared, and the pharmaceutical economics analysis was carried out.Results:The efficacy in the observation group was significantly better than in the control group (P<0.05). Before treatment, the differences in all clinical symptom score were not significant (P>0.05). After treatment, the score of abdominal distention and anorectal symptoms in the observation group were significantly lower (P<0.05) than in the control group. The cost-effectiveness ratio (C/E) of abdominal pain and anorectal symptoms in the observation group were were lower than in the control group. C/E of total efficiency in the observation group was higher than in the control group.The minimum cost of diarrhea and abdominal pain symptoms in the observation group were higher than in the control group. Conclusion:MeteoSpasmyl and Dicetel in the treatment of diarrhea predominant irritable bowel syndrome are both reliable, the former have better overall efficacy, and C/E of abdominal pain and anorectal symptoms are lower, while the C/E of total efficacy of the latter is lower.%目的：从药物经济学角度探讨复方枸橼酸阿尔维林治疗肠易激综合征的应用价值。方法：纳入腹泻型肠易激综合征患者92例，随机均分为两组。观察组予枸缘酸阿尔维林胶囊治疗；对照组予匹维溴铵片治疗。持续治疗8周后对比两组疗效及不良反应情况，并开展药物经济学分析。结果：观察组总体疗效明显优于对照组（P＜0.05）；治疗前两组各临床症状积分无明显差异（P＞0.05），治疗后观察组腹胀、直肠肛门不适症状积分明显低于对照组（P＜0.05）；观察组腹痛及直肠肛门不适症状的成本效果比（C/E）分别低于对照组，但观察组总有效率的C/E高于对照组；观察组腹泻、腹痛症状的最小成本高于对照组。结论：复方枸橼酸阿尔维林胶囊和匹维溴铵片治疗腹泻型肠易激综合征均较可靠，其中前者具备更优的总体疗效，对腹胀及直肠肛门不适的C/E更低，后者总体疗效的C/E更低。
  • 摘要：Objective: To analyze the “bed package to care” model of care in obstetrics and gynecology and effect of the application for clinical guidance.Methods:March 2013 to March 2014 in 105 patients admitted to this hospital as the A group,select the April 2014 to April 2015 105 patients were admitted to this hospital as the group B. A group of patients given usual care implementation mode, given the implementation of group B patients“ beds to care package ”model of care for nursing effect of two groups were compared. Results:Nursing Effect B group of patients was significantly better than patients in group A,the difference was significant, P<0.05. Nursing complaint rate of group B patients, nursing defect rate significantly lower than the A group, the difference was significant (P<0.05), group B patient satisfaction was significantly higher, the difference was significant (P<0.05). Conclusion: “Package beds to care” model of care used in obstetrics and gynecology care have better clinical results and high feasibility, improve patient satisfaction.%目的：分析“包床到护”护理模式在妇产科的应用及效果，为临床提供指导。方法：选择2013年3月～2014年3月入住本院的105年患者作为A组，选择2014年4月～2015年4月入住本院的105例患者作为B组。给予A组患者实施常规护理模式，给予B组患者实施“包床到护”护理模式，分析比较两组患者的护理效果。结果：B组患者的护理效果显著优于A组患者，差异显著，P＜0.05。B组患者的护理投诉率，护理缺陷率显著低于A组，差异有显著性（P＜0.05），B组患者满意度显著高于对照组，差异有显著性（P＜0.05）。结论：“包床到护”护理模式应用于妇产科护理具有较好的临床效果和较高的可行性，能提高患者的满意度。
  • 摘要：Objective: To explore the effect of the application of quality control circle in the prevention and nursing of skin impression caused by indwelling needle in infants and young children.Methods:My courtyard department of Pediatrics receiving indwelling needle in infant children of 268 cases,were randomly divided into observation group and control group; control group according to the conventional way of indwelling needle puncture operation observed group product management circle activities operation.Compared with the two groups of children with skin indentation and quality control circle activity group of nursing care before and after the growth of.Results:In the observation group, the indentation was 10.44% in the control group, the indentation rate was 29.78%, the experimental results (P<0.05) are statistically significant;nursing,nursing staff compared with before treatment have obvious improvement,the experimental results (P<0.05) is statistically significant.Conclusion:The quality control circle activity can effectively improve the skin impression prevention effect of indwelling needle in infants, and can effectively improve the awareness and ability of nursing staff.%目的：探究品管圈活动在婴幼儿留置针所致皮肤压痕预防护理中的应用效果。方法：选取我院儿科接收留置针管的婴幼儿患儿268例，随机平均分成观察组与对照组；对照组按照常规方式进行留置针穿刺操作，观察组使用品管圈活动操作。对比两组患儿皮肤压痕的情况及品管圈活动小组的护理人员护理前后的成长情况。结果：观察组的压痕出现率为10.44%，对照组的压痕出现率为29.78%，对比结果（P＜0.05）有统计学意义；护理后，护理人员较护理前有明显的改善，对比结果（P＜0.05）有统计学意义。结论：品管圈活动能有效提升婴幼儿留置针所致皮肤压痕预防效果，并能有效提高护理人员的预防意识与能力。
  • 摘要：目的：探讨同步放化疗对中晚期宫颈癌患者的治疗效果。方法：304例宫颈癌患者，随机平均分为单纯放疗组（D组）和同步放化疗组（T组），各152例，治疗结束对患者随访2年，观察两组治疗的有效性和毒副反应。结果：两组死亡患者为92例，D组55例，T组37例。Ⅱb期患者其死亡比低于Ⅲ期，无瘤生存比高于Ⅲ期，差异有统计学意义（P＜0.05）。Ⅱb患者D组死亡比高于T组(P＜0.05)。放化疗期间D组骨髓抑制的重度发生比和重度肠道反应的发生比均低于T组，差异有统计学意义（P＜0.05）。结论：同步放化疗对中晚期宫颈癌患者效果好。%Objective: To study the effect of concurrent radiotherapy and chemotherapy in the treatment of patients with advanced cervical cancer.Methods:304 cases of cervical cancer patients were randomly divided into radiotherapy alone group (Group D) and synchronous radiotherapy and chemotherapy group (Group T), 152 cases each. At the end of treatment, patients were followed up for 2 years and observe the effectiveness and side effect of treatment in the two groups.Results:In the two groups, 92 patients died, 55 in the group D and 37 in the group T. In B phase II patients, the ratio of death to death was lower than that of stage III, and there was a signiifcant difference (P<0.05). The death ratio of group D patients with B was higher than that in group T (P<0.05). During the period of chemotherapy, the incidence of severe intestinal reactions of group D was lower than that of group T, and the difference was statistically signiifcant (P<0.05).Conclusion:Concurrent radiotherapy and chemotherapy is effective for patients with advanced cervical cancer.
  • 摘要：Objective: To investigate the clinical significance of the determination of thyroid stimulating hormone receptor antibody (TRAb) in patients with thyroid disease.Methods:45 cases of thyroid disease patients (Study Group) for autoimmune thyroid disease (GD) group of 29 cases and 16 cases in non GD group, 45 cases over the same period healthy volunteer subjects (control group), TRAb was detected by radioimmunoassay and compared the thyroid stimulating hormone (TSH) level.Results:The level of TSH in study group were significantly lower than the control group, the level of TRAb was significantly higher than that of the control group; GD at TSH level was significantly lower than GD recurrence, TRAb level was significantly higher than that of non GD group GD recurrence; simple goiter and nodular goiter TRAb were negative, subacute thyroiditis and Hashimoto's disease (HD) the higher the positive rate of TRAb. The difference between the two groups was significant (P<0.05).Conclusion:The detection of TSH receptor antibody has important guiding significance in the diagnosis, differential diagnosis, treatment effect and prognosis of thyroid diseases.%目的：探讨甲状腺疾病患者测定促甲状腺激素受体抗体（TRAb）的临床意义。方法：45例甲状腺疾病患者（研究组）分为自身免疫性甲状腺疾病（GD）组29例和非GD组16例，另选同期健康志愿体检者45例（对照组），采用放射免疫分析法检测TRAb，比较各组促甲状腺激素（TSH）水平。结果：研究组TSH水平显著低于对照组，TRAb水平显著高于对照组；GD初诊TSH水平显著低于GD复发者，TRAb水平显著高于GD复发者；非GD组单纯性甲状腺肿和结节性甲状腺肿TRAb表现为阴性，亚甲炎和桥本氏病（HD）的TRAb阳性率较高。两组差异比较显著（P＜0.05）。结论：TSH受体抗体测定对甲状腺疾病的诊断、鉴别诊断、治疗效果及预后均有重要指导意义。
  • 摘要：Objective: To investigate the therapeutic effect and related factors of conservative surgery in the treatment of pelvic pain in patients with endometriosis.Methods:104 cases of patients with endometriosis by conservative surgery, according to pelvic pain relief were divided into remission group (66 cases) and non remission group (38 cases), and the curative effect of conservative surgery related factors analysis.Results:The curative effect of relevant bilateral pelvic lesions, adenomyosis, postoperative medication, rectouterine pouch reconstruction, presacral neurectomy 5 factors and endometriosis conservative surgery in the treatment of pelvic pain.Conclusion:The 5 factors affecting control of patients with endometriosis and pelvic pain conservative surgery curative effect, can improve the curative effect of conservative surgery for pelvic pain.%目的：探讨子宫内膜异位症患者保守性手术治疗盆腔痛的疗效及相关因素。方法：104例子宫内膜异位症患者采用保守性手术治疗，根据盆腔痛缓解情况将患者分为缓解组（66例）和未缓解组（38例），对保守性手术的疗效和相关因素进行分析。结果：双侧盆腔病变、子宫腺肌病、术后药物治疗、子宫直肠陷凹重建术、骶前神经切断术等5个因素与内异症患者保守性手术治疗盆腔痛的疗效相关。结论：控制影响内异症患者盆腔痛保守性手术疗效5个相关因素，可提高保守性手术治疗盆腔痛的疗效。
  • 摘要：目的：探讨肺泡表面活性物质（PS）联合容量目标通气（VTV）治疗新生儿呼吸窘迫综合征（NRDS）的疗效。方法：80例NRDS患儿按照随机数表法分为观察组、对照组，各40例。两组均接受常规治疗，观察组再加入PS联合VTV治疗。治疗24h后，评估两组患儿的治疗效果、动脉血气指标、血清Th1/Th2细胞因子含量。结果：两组治疗24h后，观察组治疗总有效率、基本痊愈率均高于对照组，无效率低于对照组（P＜0.05）；观察组的酸碱度、动脉血氧分压、动脉血氧分压/肺泡氧分压水平高于对照组，动脉血二氧化碳分水平低于对照组（P＜0.05）；观察组的血清Th1细胞因子干扰素-γ、白介素-1含量低于对照组，Th2细胞因子白介素-4、白介素-10含量高于对照组（P＜0.05）。结论：PS联合VTV可有效提升NRDS治疗效果、优化肺通气换气功能，恢复Th1/Th2细胞因子稳态。%Objective: To investigate the effect of pulmonary surfactant (PS) combined with the capacity of the target ventilation (VTV) in treatment of neonatal respiratory distress syndrome (NRDS) effect.Methods: 80 cases of NRDS were randomly divided into observation group and control group, 40 cases in each. The two groups were treated with conventional therapy, and the observation group was treated with PS combined with VTV. Treatment effect, arterial blood gas index, serum Th1/Th2 cytokine levels were assessed after treatment with 24h.Results:After the treatment of two groups of 24h, the total efficiency of the observation group, the basic recovery rate was higher than the control group, no efficiency is lower than that of the control group (P<0.05); the observation group pH, PaO2 and PaO2/PaO2 level higher than the control group, arterial blood carbon dioxide levels lower than the control group (P<0.05); observation group serum Th1 cytokine interferon gamma, interleukin-1 levels lower than the control group, Th2 cytokine interleukin-4 and interleukin-10 levels were higher than the control group (P<0.05).Conclusion:PS combined with VTV can effectively improve the therapeutic effect of NRDS, optimize the ventilation function of lung ventilation, and restore the stability of Th1/Th2 cytokines.
  • 摘要：Objective: To investigate the quality of life and related factors in hemodialysis patients.Methods: In the questionnaire, 65 patients with maintenance hemodialysis were used as hemodialysis group, the control group was 65 cases of physical health and effective questionnaire. The gender, age, body mass index, education level, health insurance and complications of the two groups were analyzed statistically, and the quality of life and related factors of the two groups were analyzed.Results: The 8 dimensions of hemodialysis patients (PF, RP, BP, GH, VT, SF, RE, MH) were significantly lower than those in the control group (P<0.05). Gender is female, older, lower educational level, lower body mass index, the longer dialysis time, at their own expense, the worse the quality of life of patients with complications, with statistical significance (P<0.05).Conclusion: Gender, age, body mass index, education, health care and complications were the main factors influencing the quality of life of maintenance hemodialysis patients.%目的：探讨血液透析患者的生存质量与相关因素。方法：调查问卷中有效的65例维持性血液透析患者作为血液透析组，对照组为身体健康和有效调查问卷的65例。对两组患者性别、年龄、体重指数、文化程度、医保和合并症等资料进行统计分析，分析两组的生存质量与相关因素。结果：血液透析组患者的8个维度（PF、RP、BP、GH、VT、SF、RE、MH）均显著低于对照组(P＜0.05)。性别为女性、年龄越大，文化程度越低、体重指数越低，透析时间越长，自费，具有合并症的患者生活质量越差，具有统计学意义(P＜0.05)。结论：患者的性别、年龄、体重指数、文化程度、医保和合并症等是影响维持性血液透析患者生活质量的主要因素。
  • 摘要：Objective: To investigate the effect of Buchangwenxin Granules on right ventricular function in patients with chronic pulmonary heart disease (CPHD).Methods:86 cases of CPHD were randomly divided into observation group and control group, each of 43 cases. The two groups were given anti infection, antiasthmatic, diuretic therapy, observation group were treated with Buchangwenxin Granules 9g/times, 3 times/d, 4 weeks. Echocardiography monitoring early diastolic peak velocity of right ventricle(E peak), late diastolic peak flow velocity (A peak), three tricuspid annular motion amplitude (TAPSE) and right ventricular fractional area change (RVFAC) of the two groups before and after the treatment.Results:After the treatment, the two groups of E peak, A peak, E/A ratio and TAPSE, RVFAC than before treatment were improved. The observation group E peak, A peak, E/A ratio improved significantly compared with the control group, RVFAC, TAPSE compared with the control group, there was no significant difference.Conclusion:Buchangwenxin Granules can significantly improve the right ventricular diastolic function in patients with CPHD.%目的：探讨稳心颗粒对慢性肺源性心脏病（CPHD）患者右心功能的影响。方法：86例CPHD患者随机分为观察组和对照组，各43例。两组均给予抗感染、平喘、利尿基础治疗，观察组加用稳心颗粒9g/次，3次/d，疗程4周。超声心动图监测两组治疗前后右心室的舒张早期最大血流速度（E峰）、舒张晚期最大血流速度（A峰）、三尖瓣环运动幅度（TAPSE）及右室面积变化分数（RVFAC）。结果：治疗后两组E峰、A峰、E/A比值及TAPSE、RVFAC较治疗前均改善。观察组E峰、A峰、E/A比值较对照组改善显著，TAPSE、RVFAC与对照组相比无显著差异。结论：稳心颗粒能显著改善CPHD患者的右心舒张功能。
  • 摘要：目的：探讨中药结合紫杉醇+顺铂方案治疗晚期卵巢癌对患者生存质量的影响。方法：80例卵巢癌患者随机分为观察组和对照组，各40例。应用欧洲癌症研究与质量组织生命质量问卷第三版（QLQ-C30，V3.0）和体能KPS评分法以及患者3年内生存率对两组患者生存质量进行评价。结果：观察组在躯体反应、身份角色、情绪心态、社会功能、恶心呕吐、乏力症状、食欲、睡眠困难、呼吸困难、腹泻和便秘症状中的评分明显高于对照组（P＜0.05），两组认知功能、疼痛症状的评分比较，差异无统计学意义（P＞0.05）。观察组体能KPS评分明显优于对照组（P＜0.05）。观察组随访3年内的生存率均明显高于对照组（P＜0.05）。结论：中药联合TP化疗方案治疗晚期卵巢癌患者，可提高患者生命质量，增加患者体能，提高近期生存率和生存质量。%Objective: To explore the effect of traditional Chinese medicine combined with paclitaxel plus cisplatin on the quality of life of patients with advanced ovarian cancer.Methods: 80 cases of ovarian cancer were randomly divided into the observation group and the control group, each of 40 cases. The quality of life of the two groups was evaluated by the Third Edition (QLQ-C30, V3.0) and the KPS score and the 3 year survival rate of the patients with the quality of life of the European cancer research and quality organization. Results:In the group of body reaction, identity role, social function, emotional attitude, nausea and vomiting, fatigue, appetite, sleep difficulties, dyspnea, diarrhea and constipation symptom scores in the observation was significantly higher than the control group (P<0.05), compared with two groups of cognitive function, the pain symptom score, the difference was not statistically significant (P>0.05). The KPS score of observation group was significantly better than that of control group (P<0.05). The survival rate of the observation group was significantly higher than that of the control group (P<0.05) in 3 years.Conclusion: Traditional Chinese medicine combined with TP chemotherapy in the treatment of patients with advanced ovarian cancer can improve the quality of life, increase the physical fitness, and improve the survival rate and quality of life in patients with advanced ovarian cancer.
  • 摘要：Objective: To investigate the effects of dexmedetomidine and fentanyl on blood gas in patients with lung surgery and cerebral oxygen saturation.Methods: 80 patients underwent lobectomy of lung cancer patients were randomly divided into control group and experimental group, 33 cases each. The patients underwent lobectomy, two groups were treated with fentanyl, propofol, experimental group given dexmedetomidine, after surgery, PO2, PCO2, rSO2, MMSE score and patient recovery time, extubation time.Results:Compared with before treatment, rSO2 patients, MMSE scores were decreased after treatment, PO2 level increased; compared with the control group, experimental group rSO2, MMSE score and PO2 level is higher, the recovery time, extubation time is short; no changes in PCO2 patients before and after treatment.Conclusion:Dexmedetomidine and fentanyl can increase the level of PO2 in patients with lung surgery patients, delay the decrease of cerebral oxygen saturation level, had no effect on the level of PCO2.%目的：探讨右美托咪啶与芬太尼对肺部手术患者血气以及脑氧饱和度的影响。方法：80例行肺叶切除手术肺癌患者，随机分为对照组和试验组，各33例，患者均行肺叶切除术，两组均用芬太尼、丙泊酚麻醉，试验组再给予右美托咪啶，手术结束后，比较PO2、PCO2、rSO2、MMSE评分以及患者苏醒时间、拔管时间。结果：与治疗前相比，治疗后患者rSO2、MMSE评分水平均下降，PO2水平升高；与对照组相比，试验组患者rSO2、MMSE评分以及PO2水平较高，苏醒时间、拔管时间较短；患者治疗前后PCO2无变化。结论：右美托咪啶与芬太尼能够升高肺部手术患者PO2水平，延缓患者脑氧饱和度水平的下降，对PCO2水平无影响。
  • 摘要：目的：对我院2014～2015年住院患者调血脂药物使用情况进行分析。方法：对我院2014～2015年患者住院期间使用调血脂药物的销售金额、用药频度（DDDs）、限定日费用（DDC）等进行回顾性统计分析，利用销售金额与DDDs排序比对药物同步性进行比较、分析。结果：我院调血脂药物的使用量呈上升趋势，其中他汀类调血脂药的销售金额及DDDs在2014～2015年住院患者调血脂药中排序稳居首位，同步性较好，符合国内临床使用调血脂药趋势及治疗原则。结论：我院2014～2015年调血脂药物使用情况基本合理。%Objective: To compare and analyze the usage of lipid-lowing agents in our hospital during 2014~2015.Methods: Sales amount of lipid-lowing agents, DDDs (DDDs) and defined daily cost (DDC) were retrospectively analyzed of inpatients in our hospital during 2014~2015. Analyze the use of lipid-lowing agents according to the DDDs order and sum order.Results: The use of lipid-lowing agents in our hospital showed a rising trend year by year. Statins was the top of lipid-lowing agents by the DDDs order, which conformed to the clinical medication trend and treatment principles.Conclusions:The use of lipid-lowing agents in our hospital during 2014~2015 was basically reasonable.
  • 摘要：Objective: To explore the effect of evidence-based nursing in the combination of tumor surgery and tumor free technique.Methods:188 cases of tumor patients in nursing were divided into control group and study group, each of 94 cases, control group received routine nursing care, the study group with the implementation of evidence-based nursing, the nursing effects were compared between the two groups.Results:The qualified rate of the patients in the study group was significantly higher than that of the control group,P<0.05, the incidence of nursing errors in the study group, the rate of nursing complaints was significantly lower than that of the control group,P<0.05. Compared with the control group, the rate of abdominal wall implantation was significantly lower in the study group than in the control group, the survival rate of the patients in the study group was significantly higher than that in the control group (P<0.05).Conclusion: The application of evidence-based nursing intervention in the combination of tumor surgery and tumor free technology can enhance the effectiveness and scientific of surgical nursing, improve the survival rate and improve the quality of nursing.%目的：探讨肿瘤手术无瘤技术配合中应用循证护理的效果。方法：188例肿瘤手术患者按照护理方法分为对照组和研究组，各94例，对照组患者实行常规护理，研究组患者实行循证护理，比较两组患者的护理效果。结果：研究组患者的基础护理合格率显著高于对照组，P＜0.05,研究组患者的护理差错发生率、护理投诉率显著低于对照组，P＜0.05。研究组的患者较对照组，肿瘤腹壁种植率明显偏低；研究组在术后1年患者存活率则比对照组明显要高（P＜0.05）。结论：肿瘤手术无瘤技术配合中运用循证护理干预措施，能增强手术护理的有效性及科学性，提高生存率，提高护理质量。
  • 摘要：Objective: To To investigate the effect of serum levels of CYFRA21-1 and SCCAg in cervical cancer patients on tumor prognosis of patients with cervical cancer radiotherapy.Methods:50 cases of cervical cancer patients by radioimmunoassay 50 levels of CYFRA21-1 and serum SCCAg detection method,using Pearson and Spearman correlation analysis the relationship between serum CYFRA21-1 and SCCAg levels and clinical characteristics of patients with cervical cancer,using COX regression model to analyze the CYFRA21-1 and SCCAg levels in patients with cervical cancer or died of recurrence and metastasis of the the relationship between.Results:50 cases of patients with cervical cancer,11 cases of endpoint events,LNR4 patients have a higher risk of events about 44.5%,CYFRA21-1 and SCCAg levels and CA-125 in patients with cervical cancer,tumor N staging,depth of tumor invasion was positively correlated,no obvious correlation with age,degree of tumor differentiation (P=0.013),the serum level of CYFRA21-1 (P=0.02),the serum level of SCCAg (P=0.03),depth of tumor invasion (P=0.04) is an independent risk factor outcome in patients with cervical cancer.Conclusion:The levels of CYFRA21-1 and SCCAg are closely related to the prognosis of patients with cervical cancer radiotherapy.%目的：探讨宫颈癌患者血清中CYFRA21-1和SCCAg水平对宫颈癌放疗患者肿瘤预后的影响。方法：50例宫颈癌的患者50采用放射免疫检测法检测患者血清中CYFRA21-1和SCCAg水平，采用Pearson和Spearman相关性分析血清中CYFRA21-1和SCCAg水平与宫颈癌患者临床特征的关系，采用COX回归模型分析CYFRA21-1和SCCAg水平与子宫颈癌患者死亡或转移复发的的关系。结果：50例宫颈癌患者，出现终点事件者11例，LNR4期患者出现终点事件的风险较高约44.5%，CYFRA21-1和SCCAg水平均与宫颈癌患者CA-125值、肿瘤的N分期、肿瘤侵犯深度成正相关，与患者年龄无明显相关，肿瘤分化程度（P=0.013）、血清CYFRA21-1水平（P=0.02）、血清SCCAg水平（P=0.03）、肿瘤侵犯深度(P=0.04)是宫颈癌患者出现终点事件的独立危险因素。结论：CYFRA21-1和SCCAg水平对宫颈癌放疗患者肿瘤预后密切相关。
  • 摘要：Objective: To explore the inlfuence of individualized nursing on the quality of life of patients with advanced lung cancer.Methods:96 patients with advanced lung cancer were randomly divided into control group and experimental group, 48 cases in each group, two groups were given routine nursing, the experimental group was given nursing staff to give personalized nursing intervention. The quality of life of two groups of patients were measured tenth days after admission with the core of quality of life (QLQ-C30).Results: After the individualized nursing intervention, the quality of life of the experimental group was signiifcantly higher than that of the control group,P<0.05.Conclusion: Individualized nursing can effectively improve the quality of life of patients with advanced lung cancer, and improve the living conditions of patients with advanced lung cancer.%目的：探讨个性化护理对晚期肺癌患者生活质量的影响。方法：96例肺癌晚期患者随机分为对照组和试验组，各48例，两组均给予医院常规护理，实验组再由护理人员给予个性化护理干预。采用生活质量核心量表（QLQ-C30）测量两组患者入院后第10天的生活质量。结果：经个性化护理干预后，试验组生活质量明显高于对照组，P＜0.05。结论：个性化护理可有效提高晚期肺癌患者的生活质量，改善患者生活状态。
  • 摘要：Objective: To evaluate the impact of health care reform trial implemented in pilot hospital of Beijing in 2012. Methods:Data of 463 hospitalized patients with diabetes mellitus was retrospectively drawn,medical expense and length of stay during 2010~2014 was compared. Result:Through the health care reform,the length of stay was shorten(P=0.00),the proportion of drug expense was decreased(P=0.02),the proportion of medical service fee was increased.Conclusion:The health care reform reflected the value of physician knowledge of labor and improves the operational efficiency of hospital.%目的：探讨2012年北京市属医院试行医改措施对糖尿病患者住院指标的影响。方法：调查分析2010～2014年某试行医改工作三级甲等医院糖尿病住院患者463例的医疗费用和住院日等指标，比较医改前后差异。结果：施行医改后糖尿病患者平均住院日明显缩短（P=0.00）；在总体住院费用无明显变化的情况下，医改后诊疗费及诊疗占比显著提高（P=0.00），药占比有所下降（P=0.02）。结论：医改措施体现了医务人员劳动价值，提高了医院运营效率。
  • 摘要：功能神经外科是神经外科的一个重要分支,是通过外科手术技术对中枢神经系统的功能失调来进行改善、缓解症状、恢复神经功能。与普通神经外科相比,功能神经外科中的疾病特点及诊断有很大特殊性,很多先进技术及科技产品在手术治疗中得到运用。但我国的功能神经外就整体水平而言还有待提高,地域发展也极为不平衡,严重缺乏专业的功能神经外科医生,需对神经外科研究生及进修医生进行专业培养。
  • 摘要：Objective: To investigate the clinical characteristics of acute ST segment elevation myocardial infarction (STEMI) and non ST segment elevation acute coronary syndrome (NSTE-ACS) and the characteristics of coronary artery disease.Methods:146 patients with emergency percutaneous coronary intervention (PCI) were divided into group AMI (112) and group NSTE-ACS (34 patients). The clinical characteristics and coronary artery lesion characteristics were observed in the two groups.Results:There were no significant differences in gender, age, length of stay, past medical history between the two groups. The risk factor, smoking history, might be an indicatorfor the STEMI compared with the NSTE-ACS (P=0.076). The white blood cell in theSTEMI group was significantly higher than that of the NSTE-ACS group(P=0.041). The left circumflex artery (LCX),which is a culprit artery, caused more NSTE-ACS than STEMI; however, the dysfunction of right coronary artery (RCA) was more common(P=0.011) than the LCX. in the STEMI group.It was shown in the angiography, thrombosis in the group STEMI was significantly higher than that in the group NSTE-ACS(P=0.014). There was no significant difference between the two groups in the other pathological changes.Conclusion:Smoking history, as well as the increased white blood cells at admission stage,is more common in the group STEMI patients than that in the group NSTE-ACS. The dysfunction of LCX lead more NSTE-ACS, and that of RCA lead more STEMI, while thrombosis is much often seen in the STEMI group from the angiography.%目的：探讨急性ST段抬高型心肌梗死（STEMI）与非ST段抬高型急性冠状动脉综合征（NSTE-ACS）临床特征及冠状动脉病变特点。方法：146名行急诊冠脉介入治疗（PCI）患者分为STEMI组（112名）和NSTE-ACS组（34名）。观察两组患者基线临床特点及冠脉病变特征。结果：两组患者的性别、年龄、住院时间、既往病史、差异均无统计学意义。冠心病危险因素中吸烟史STEMI组较NSTE-ACS组有增多趋势（P=0.076）。STEMI组白细胞较NSTE-ACS组明显升高（P=0.041）。冠脉病变STEMI组罪犯血管为左回旋支（LCX）的显著少于NSTE-ACS组，但右冠状动脉（RCA）的更多见（P=0.011），STEMI组造影发现血栓显著多于NSTE-ACS组（P=0.014）。两组在其余病变特点差异均无显著性。结论：STEMI患者较NSTE-ACS更多伴有吸烟史，入院时白细胞更高，LCX的显著少于NSTE-ACS组，RCA的更多。行急诊PCI时STEMI组造影血栓更多见。
  • 摘要：Objective: To investigate the effect of mycoplasma infection (MP) on T cell subsets, inflammatory factors and clinical symptoms in children with allergic purpura (HSP).Methods: 96 cases of HSP were divided into MP positive group (30 cases in group A, MP) and negative group (group B, 66 cases), CD3+, CD4+, CD8+, CD19+ and NK subsets in contrast to its T cell (16++56+) percentage and serum inflammatory factors IL-6, IL-17 and TGF- levels. Comparison of two groups of children with skin rash subsided time, hospitalization time and the incidence of adverse symptoms during the follow-up period.Results:There were no significant differences in the percentages of CD3+, CD4+, and CD19+ in the two groups of T cell subsets (P>0.05), while the CD8+, CD4+/CD8+, CD (16++56+) of A group was lower than that of B group (P<0.05). A group IL-6, IL-17 was significantly higher than B group (P<0.05), the two group of TGF- beta did not show significant difference (P>0.05). The time of rash subsided and hospital stay in group A were significantly higher than those in B group, and the incidence of abdominal pain, joint pain, recurrence and other adverse symptoms during hospitalization and follow-up were higher than that in group B (P<0.05).Conclusion: MP infection can inhibit the NK activity of immune cells, promote the secretion of Th17 and other inflammatory factors, aggravate the imbalance of T cell subsets, lead to excessive proliferation of B cells, resulting in HSP group is more serious immune dysfunction, leading to a more severe clinical response.%目的：探讨支原体感染（MP）对过敏性紫癜（HSP）患儿的T细胞亚群、炎症因子及临床症状的影响。方法：96例HSP患儿分为MP阳性组（A组，30例）与MP阴性组（B组，66例），对比其T细胞亚群中CD3+、CD4+、CD8+、CD19+及NK(16++56+)的百分比，及血清炎症因子IL-6、IL-17、TGF-β水平，比较两组患儿的皮疹消退时间、住院时间及随访期间不良症状的发生率。结果：两组T细胞亚群中CD3+、CD4+、CD19+的百分率不存在显著差异（P＞0.05），而A组的CD8+、CD4+/CD8+、CD(16++56+)则低于B组（P＜0.05）。A组IL-6、IL-17明显高于B组（P＜0.05），两组的TGF-β则未见显著差异（P＞0.05）。A组皮疹消退时间、住院时间显著高于B组，住院及随访期间腹痛、关节痛、复发等不良症状的发生率也均高于B组（P＜0.05）。结论：MP感染可抑制NK免疫细胞活性，促进Th17等炎症因子的分泌，加重T细胞亚群的失衡，导致B细胞过度增殖，引起HSP患儿更为严重的免疫功能紊乱，导致更为严重的临床反应。
  • 摘要：目的：探讨Y染色体性别决定区相关高速泳动族框因子9（SOX9）蛋白在喉鳞癌组织中的表达及临床意义。方法：采用免疫组织化学方法对喉正常黏膜及喉鳞癌组织中的SOX9蛋白进行检测，分析SOX9蛋白表达与临床病理因素之间的关系。结果：SOX9蛋白在喉鳞癌组织中表达水平显著高于正常喉组织(P＜0.01)；SOX9蛋白在不同喉组织中的表达水平与淋巴结转移、临床分期有关(P＜0.05)。结论：SOX9蛋白在喉鳞癌组织中高表达与喉鳞癌的浸润转移有关。%Objective: To investigate the expression and clinical significance of Y chromosome 9 (SOX9) protein in laryngeal squamous cell carcinoma (SCC).Methods:SOX9 protein was detected by immunohistochemistry in normal laryngeal mucosa and laryngeal squamous cell carcinoma, and the relationship between the expression of SOX9 protein and clinical pathological factors was analyzed.Results: The expression level of SOX9 protein in laryngeal squamous cell carcinoma was significantly higher than that in normal laryngeal tissues(P<0.01). The expression of SOX9 protein in different laryngeal tissues was related to lymph node metastasis and clinical stage(P<0.05).Conclusion:The high expression of SOX9 protein in laryngeal squamous cell carcinoma was related to the invasion and metastasis of laryngeal squamous cell carcinoma.
  • 摘要：目的：观察螺内酯联合缬沙坦/氨氯地平及氢氯噻嗪治疗老年难治性高血压的临床效果。方法：70例老年难治性高血压患者，采取病例自身治疗前后血压进行对照研究，给予患者螺内酯20mg/d，缬沙坦/氨氯地平85mg/d或170mg/d口服，同时氢氯噻嗪片12.5mg/d，早起后口服；每天记录1次血压、心率、临床症状和不良反应等情况，疗程8周；期间4周左右可视血压情况调整缬沙坦/氨氯地平用量；治疗前后检测血生化、血常规和尿常规等；治疗前、治疗4周和治疗8周时行24h动态血压监测评估血压情况。结果：本组70例老年难治性高血压患者经治疗后血压达标率达97.1%，各项生化检查指标无明显改变。结论：螺内酯联合缬沙坦/氨氯地平及氢氯噻嗪是治疗老年难治性高血压的有效药物。%Objective: To observe the clinical effects of spironolactone combine with valsartan/amlodipine and hydrochlorothiazide in the treatment of geriatric resistant hypertension.Methods:A total of 70 patients with geriatric resistant hypertension were included, and the pre-/post-treatment blood pressure before and after treatment were compared. Patients were given spironolactone 20mg/day, combined with valsartan/amlodipine 85mg/day or 170mg/day and hydrochlorothiazide 12.5mg/day po in the morning, and everyday recorded blood pressure, heart rate, clinical symptoms and adverse reaction etc once. The course of treatment was 8 weeks. valsartan/amlodipine can be adjusted depending on patients blood pressure in the fourth week. We tested the patients’blood biochemical, blood routine, urine routine and etc before and after treatment. 24 hours ambulatory blood pressure monitoring was performed before the treatment, 4 weeks during the treatment, and 8 weeks during the treatment.Results:In the 70 cases of geriatric resistant hypertension, the targeted-BP goal rate was 97.1% after treatment, and the biochemical indexes had no obvious change.Conclusion:Spironolactone combine with valsartan/amlodipine and hydrochlorothiazide is effective for the treatment of geriatric resistant hypertension.
  • 摘要：Objective: To observe the clinical effect of calcipotriol combined with Mannatide Capsules in the treatment of psoriasis vulgaris.Methods: 70 patients with psoriasis vulgaris were randomly divided into control group (35 cases) andtreatment group (35 cases). In the control group, the treatment group was treated with calcipotriol, and the treatment group was added with Mannatide Capsules on the basis of the treatment of calcipotriol. The course of treatment was 12 weeks.Results:The treatment efifciency of 12 weeks, the treatment group was 91.43%, the control group was 68.57%, the treatment group was signiifcantly higher than the control group (P<0.05).Conclusion:The combined use of calcipotriol l and the treatment of psoriasis vulgaris with the use of the card, the effect is fast, can improve the clinical effect.%目的：观察卡泊三醇联合甘露聚糖肽胶囊治疗寻常型银屑病的临床效果。方法：70例寻常型银屑病患者随机分为对照组（35例）和治疗组（35例）。对照组使用卡泊三醇治疗，治疗组在卡泊三醇的治疗基础上加用甘露聚糖肽胶囊。疗程均为12周。结果：治疗12周有效率，治疗组为91.43%，对照组为68.57%，治疗组显著高于对照组（P＜0.05）。结论：联合使用卡泊三醇和甘露聚糖肽治疗寻常型银屑病，起效快，能提高临床效果。
  • 摘要：Objective: To investigate the effect of different doses of glucocorticoids in the treatment of pain in patients with herpes zoster.Methods: 84 cases of herpes zoster patients with neuropathic pain were randomly divided into observation group and control group, 42 cases in each, were treated with valaciclovir and pregabalin for regular antiviral therapy, while the control group was given small dose of prednisone (20mg/d), the observation group was given moderate doses of prednisone (40mg/d), were treated for 2 weeks, compared with two groups of check global time, bulla disappeared time, the time of incrustation and decrustation, and application of the simplified McGill pain questionnaire evaluation of two groups before and after treatment for 1 weeks, 2 weeks after the treatment of pain, and observe the adverse reaction.Results:The observation group for global time, blisters disappearing time, scab, decrustation time was shorter than the control group (P<0.05); the observation group after treatment for 1 weeks and 2 weeks after treatment McGill pain scores were lower than the control group and before treatment (P<0.05); adverse reactions of two groups were no significant difference (P>0.05).Conclusion:The application of medium dose glucocorticoid relief effect of herpes zoster virus in patients with nerve pain better, can reduce the bubble stopping time, bubble disappearance time and the time of incrustation and decrustation, light adverse reactions.%目的：探讨不同剂量糖皮质激素在缓解带状疱疹患者神经疼痛中的疗效。方法：84例带状疱疹伴神经疼痛患者采用随机数表法分为观察组和对照组，各42例，均给予伐昔洛韦与普瑞巴林行正规抗病毒治疗，同时对照组给予小剂量（20mg/d）泼尼松，观察组给予中等剂量（40mg/d）泼尼松，均治疗2周，比较两组止泡时间、水泡消失时间、结痂时间、脱痂时间，同时应用简化McGill疼痛量表评价两组治疗前及治疗后1周、治疗后2周疼痛度，并观察不良反应。结果：观察组止泡时间、水泡消失时间、结痂时间、脱痂时间明显短于对照组（P＜0.05）；观察组治疗后1周、治疗后2周McGill疼痛评分均低于对照组及治疗前（P＜0.05）；两组不良反应发生率比较无显著差异（P＞0.05）。结论：应用中等剂量糖皮质激素缓解带状疱疹病毒患者神经疼痛效果较好，可减少止泡时间、水泡消失时间、结痂时间、脱痂时间，不良反应轻。

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