Δ9-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory

摘要

RationaleCannabis users display a constellation of withdrawal symptoms upon drug discontinuation, including sleep disturbances, irritability, and possibly memory deficits. In cannabinoid-dependent rodents, the CB1 antagonist rimona-bant precipitates somatic withdrawal and enhances forskolin-stimulated adenylyl cyclase activity in cerebellum, an effect opposite that of acutely administered Δ⁹-tetrahydrocannabinol (THC), the primary constituent in cannabis.