New Multiparameter Bioanalytical Technologies for Applications in Personalized Medicine Drug Discovery and Fundamental Biology

摘要

The ability to determine expression levels of multiple genetic and/or proteomic signatures simultaneously from the same sample volume is of tremendous importance in a wide range of biomedical applications including disease diagnostics, drug discovery, and fundamental studies of complex biological processes. Unfortunately, many of the tremendously enabling genomic and proteomic technologies available to the academician are not applicable in the clinical setting. Combining traditional chemical and biological insight with cutting-edge concepts from materials science, physics, and engineering, our group brings an interdisciplinary approach to developing new tools to tackle longstanding, refractory problems in the biological sciences—technologies that will enable fundamental biological discovery, and in some applications, expedite the transfer of biomolecular insight to the hands of the physician where it can directly impact patient care.