ObjectiveTo study the curative effect of treating chronic systolic heart failure by using spironolactone combined with Fosinopril.Methods94 cases of chronic heart failure patients,were randomly divided into control group (n=48 cases)and treatment group(n=46 cases). Besides using Diuretic and Beta Blockers as usual,the treatment group added spironolactone Tablets and Fosinopril and observed the patients for 1 years. Then compared left ventricular diastolic diameter(LVDd),left ventricular ejection fraction(LVEF).ResultsThe ultrasonic indicators of the treated patients in these two groups got improved,but their Left ventricular end-diastolic diameter of the patients in the treatment group were reduced more greatly,their left ventricular ejection fraction were risen,but there were statistically significant difference(P<0.01).ConclusionThe treatment by using spironolactone tablets combined with fosinopril to treat chronic systolic heart failure can control left ventricular remodeling,improve cardiac function.%目的:研究螺内酯联合福辛普利治疗慢性收缩性心力衰竭的疗效。方法选取94例慢性心力衰竭患者,随机分为对照组(n=48例)和治疗组(n=46例),常规使用利尿剂、β受体阻滞剂,治疗组加用福辛普利和螺内酯,观察时间1年。对比治疗前后左心室舒张末期内径(LVDd)、左心室射血分数(LVEF)。结果2组治疗后超声指标均得到改善,治疗组LVDd缩小、LVEF提高程度均显著优于对照组(P<0.01)。结论螺内酯联合福辛普利能抑制慢性心力衰竭患者的左室重构,提高心功能。
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