Study on the Therapeutic Effects of Low-energy Laser Therapy Combined with Cyclophosphamide on the Mouse Ascites Sarcoma

摘要

Subjective: By using the experimental model of mouse S180 ascites sarcoma, the feasibility and mechanism of low-energy laser therapy combined with the traditional antitumor drug of cyclophosphamide in the treatment of malignant tumors were discussed. Method:The S180 ascites sarcoma suffering BALB/c mice were irradiated upon the Harder's glands with the dosages of 11.00, 14.67 and 22.00 J/cm~2 respectively, and/or injected with CYT intraperitoneally to evaluate the therapeutic effects of CYT/LELT combination on malignant tumors. Results: the three dosages of LELT combined with CYT all showed remarkably therapeutic effects on the mouse S180 ascites sarcoma. Comparatively, the dosage of 14.67J/cm~2 LELT combined with CYT showed the most ideal therapeutic effects and the survival time was up to 20.80days, and the life prolongation ratio was 33.33% which was remarkably higher than those of the CYT and tumor control groups. Conclusion: CYT/LELT combined therapy had remarkably inhibiting effects on the mice ascites growth because of the existence of CYT.