Transgenic animal, embryo, transgenic mouse, animal model for the study of bone density modulation, isolated cell, nucleic acid to mark the gene by homologous recombination, and methods to study bone mass determinants, to study bone mass modulators, to study bone mass, to study an hbm effect on bone disorders, to identify surrogate markers of bone formation / resorption, to study hbm effects on cardiac disorders, to assess cardio-protective treatments for bone mass modulation effects, to modulate bone density, to produce a transgenic mouse and to identify genes associated with bone mass

摘要

"TRANSGENIC ANIMAL, EMBRYO, TRANSGENIC MICE, ANIMAL MODEL FOR STUDY OF BONE DENSITY MODULATION, ISOLATED CELL, NUCLEIC ACID TO MARK THE GENE BY HOMOLOGICAL RECOMBINATION, STUDY METHODS FOR STUDY STUDENTS TO STUDY BONE MASS, TO STUDY A HBM EFFECT ON BONE DISTURBES, TO IDENTIFY BONE TRAINING / REHABILITATION MARKERS, TO STUDY HBM EFFECTS OF CARDOSAL DIFFERENCE EFFECTS to modulate bone density, to produce a transgenic mouse and to identify genes associated with bone mass. " The present invention relates to methods and materials used to express HBM protein in animal and transgenic animal cells. The present invention also relates to transgenic animals expressing the high bone mass gene, the corresponding wild type gene and mutants thereof. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases. involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.