Method for regulating lrp5, lrp6 or hbm activity in a patient, and dkk-wnt pathway in a patient, to modulate bone mass and lipid levels in a patient, to diagnose high or low bone mass and / or high or low lipid levels in a patient to screen a compound that modulates dkk interaction with lrp5, lrp6, hbm or a dkk binding fragment of lrp5, lrp6 or hbm, and dkk with a protein that interacts with dkk, composition, pharmaceutical composition, methods for identifying compounds that modulate dkk and lrp5 / lrp6 / hbm interactions, and for identifying binding partners for a dkk protein, nucleic acid encoding a dkk-interacting peptide protein aptamer , vector, method for detecting a modulating activity of a transgenic animal compound, method for identifying potential compounds that modulate dkk activity, peptide aptamer, antibody or antibody fragment, and methods for identify dkk-interacting proteins by modulating dkk's interaction with the wnt signaling pathway, to identify compounds that modul

摘要

"METHODS FOR ADJUSTING THE ACTIVITY OF LRP5, LRP6 OR HBM IN A PATIENT, AND THE DKK-WNT PATH IN A PATIENT, TO MODULATE BONE MASS AND LEVEL BONE / HIGH BONE / DIAGNOSTIC DIAGNOSIS OR HIGH OR LOW LIPID LEVELS IN A PATIENT, TO CREATE A COMPOUND THAT MODULATES DKK INTERACTION WITH LRP5, LRP6, HBM OR A DKK LINK FRAGMENT OF LRP5, LRP6 OR HBM, AND A PROTEK WITH DIKK WITH DKK, COMPOSITION, PHARMACEUTICAL COMPOSITION, METHODS FOR IDENTIFYING COMPOUNDS THAT MODULE DKK AND LRP5 / LRP6 / HBM INTERACTIONS, AND FOR IDENTIFYING PARKING PARTNERS FOR A NUCLET PROKIN DUCKY PROKIN CODE DKK, VECTOR, METHOD FOR DETECTING A TRANSGENIC COMPOUND MODULATOR ACTIVITY, METHOD FOR IDENTIFYING POTENTIAL COMPOUNDS THAT MODULE PEKTIDIC APTITUDE, ANTIBODY OR FRAGMENT, AND ANTIBODY IDENTITY GET PROTEINS THAT INTERACT WITH DKK BY MODULATING DKK INTERACTION WITH THE WNT SIGNALING WAY TO IDENTIFY COMPOUNDS THAT MODULE DKK INTERACTION TO TEST COMPOUNDS THAT DAMAGE A MK DIFFERING AND COMPACTING A DKK TO CREATE CONWOSTS OR COMPOSITIONS THAT MODULATE DKK INTERACTION AND A PROTEIN INTERACTING WITH DKK ". The present invention provides reagents, compounds, compositions and methods that relate to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5) and / or LRP6 with Dkk including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and treatment methods of the present invention are related and collide with Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM and Wnt are implicated in bone and lipid cell signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and / or bone mass and is useful in treating and diagnosing abnormal lipid levels and bone mass disorders, such as osteoporosis.