手性芳基邻二醇的不对称合成

摘要

Chiral aryl vicinal diols with special functional group are potentially valuable synthetic intermediates for the preparation of pharmaceuticals, agrochemicals and pheromones.In recent years, the synthesis and application of chiral aryl vicinal diols have attracted intensive attention of chemists.Recent progress in asymmetric synthesis of chiral aryl vicinal diols is reviewed in both biocatalytic and chemocatalytic perspectives.The effects of some factors, including the electronic effects and steric factors of substituted groups, the species of chiral catalysts and the different reaction media, on the yields and optical activity of chiral aryl vicinal diols are summarized.The trends in the asymmetric synthesis of chiral aryl vicinal diols are prospected.%具有特定功能基团的手性芳基邻二醇是许多具有特殊功能的药物、农药和信息素的重要中间体,近年来手性芳基邻二醇类化合物的合成与应用研究引起了人们的广泛关注.本文从生物催化不对称合成和化学催化不对称合成两方面综述了近年来手性芳基邻二醇的合成进展,概述了前手性底物上取代基的电子效应和空间效应、手性催化剂的种类和反应体系等因素对合成手性芳基邻二醇产率及光学活性的影响,并对手性芳基邻二醇不对称合成的发展趋势进行了展望.