蛛网膜下腔出血患者GFAP、S100B的表达与预后相关性研究

摘要

Objective To determine the levels of serum glial fibrillary acidic protein(GFAP)and S100B protein in the patients with subarachnoid hemorrhage(SAH),and to investigate their correlation with early brain injury and prognosis in SAH.Methods The SAH patients treated in the hospital from September 2012 to September 2015 were selected as the case group and the individu-als undergoing physical examination served as the control group.The levels of serum GFAP and S100B protein on 1,2,3,6 d after onset were detected by adopting the enzyme-linked immunosorbent assay.All cases were evaluated by using NIHSS at the corre-sponding time points.The cases of disease onset more than 6 months were performed the GOS scoring.Results The levels of serum GFAP and S100B protein on 1,2,3,6 d after onset had statistical difference between the case group and control group(P<0.05). The levels of serum GFAP and S100B protein after SAH were positively correlated with early cerebral injury after SAH and nega-tively correlated with prognosis,the difference was statistically significant(P<0.05).Conclusion The expression levels of serum GFAP and S100B can reflect the degree of early brain injury after SAH and provide a basis for the assessment of early brain injury after SAH and prognosis.%目的 测定珠网膜下腔出血(SAH)患者血清胶质纤维酸性蛋白(GFAP)、S100B蛋白表达水平,探讨其与SAH早期脑损伤及预后的相关性.方法 选取该院2012年9月至2015年9月收治的SA H患者作为病例组,健康体检者为对照组,采用酶联免疫吸附实验检测SAH患者发病后1、2、3、6天血清GFAP和S100B蛋白表达水平,所有患者在相应时间点进行美国国立卫生研究院神经功能缺损评分,并于发病后6个月对以上患者进行格拉斯哥预后(GCS)评分.结果 病例组发病后第1、2、3、6天血清GFAP、S100B水平与对照组比较差异有统计学意义(P<0.05),SAH后患者血清GFAP、S100B蛋白水平均与SAH早期脑损伤程度呈正相关性,与预后呈负相关性,差异均有统计学意义(P<0.05).结论 SAH后血清GFAP、S100B表达水平可反映SA H早期脑损伤程度,为临床评估SA H早期脑损伤及预后提供依据.