P2X7受体是ATP门控的离子通道,对二价阳离子有较强的选择性,属于嘌呤受体P2X家族.P2X7受体参与细胞信号转导、细胞因子的分泌等多种生理功能.近年研究发现P2X7受体通过增加氧化磷酸化及细胞内ATP的储备,介导细胞的存活与生长.在乳腺癌中P2X7受体表达异常,并能激活JNK/SAPK途径,诱导乳腺癌细胞凋亡.本文综述了P2X7受体与乳腺癌发生发展分子机制的相关研究.%P2X7 receptor is an ATP - gated cation channel, which can choose the bivalent cation freely, and belongs to purine receptors P2X family. P2X7 receptors joins in cell signal to the report, the discharge of physical features. In recent years, researchers have discovered P2X7 receptors by increasing oxidation phosphoric acid and cells within the ATP reserves, a report that the cells to live and grow. P2X7 receptor is expresssed abnormally in breast cancer , and the P2X7 receptor can activate the JNK / SAPK pathway, inducting the apoptosis in breast cancer cells. This article reviews the development of molecular mechanisms of the P2X7 receptor and breast cancer.
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