摘要:Objective To evaluate the effects of stanozolol on the bone mineral density (BMD) and bone biomechanical prop-erties of rats with glucocorticoid (GC)-induced osteoporosis (OP). Methods Twenty-eight male Sprague-Dawley rats of3-month old were randomly divided into Group A (the basal control group), Group B (the age-matched control group), GroupC (GC-induced OP group) and Group D (stanozolol-administtated group), 7 in each group. The rats in Group A were killedwhen experiment commenced, and those in Group B were given normal saline ig., while those in Groups C and D received theprednisone acetate (4.5 mg/kg, twice a week) alone and in combination with stanozolol (0.5 mg/kg, 6 times a week), respec-tively. Ninety days later, the bilateral femur and the 5th lumbar vertebra of the rats were isolated for BMD test using dual-en-ergy X-ray absorptiometry scanner, and the torsion test, three-point bending test and compression test using electronic testingdevice. Results Compared with Group B, the mean BMD of the femur and the 5th lumbar vertebra in Group C decreased by14.64% (P<0.01), the BMD of the bilateral distal femoral segment and the 5th lumbar vertebra decreased by 21.42% (P<0.01),19.62% (P<0.05) and 23.48% (P<0.01) respectively. The load that the femur withstood in three-point bending test decreasedby 17.1% (P<0.05), and the other biomechanical parameters also declined. When compared with Group C, the BMD in GroupD increased, the torsional angle of the femur increased by 72.5% (P<0.05) and the other biomechanical parameters also tendedto increase. Conclusions BMD and biomechanical properties of the rat femur and the 5th lumbar vertebra decrease in re-sponse to a long-term GC administration, which can be prevented by stanozolol.%目的:探讨司坦唑醇对糖皮质激素(GC)所致大鼠骨质疏松的骨密度和力学性能影响.方法28只3月龄雄性SD大鼠,体质量(226±12)g,随机等分为基础对照(A)组、年龄对照(B)组、激素模型(C)组和司坦唑醇预防(D)组.C组和D组大鼠均喂醋酸泼尼松4.5 mg/kg@b.w.,每周2次,D组同时每天饲喂司坦唑醇0.5 mg/kg@b.w..3月后,用双能X线吸收骨密度测量扫描仪对各组的离体双侧股骨和第5腰椎进行骨密度测定,然后用SWD-10型材料试验机行股骨干的扭转、三点弯曲和腰椎的压缩试验.结果与B组比较,C组股骨、腰椎总骨密度减少了14.64%(P<0.01);右、左股骨远段和腰椎的骨密度分别减少了21.42%(P<0.01)、19.62%(P<0.05)和23.48%(P<0.01);与C组比较,D组的BMD均稍有增加.与B组比较,C组股骨三点弯曲的载荷减少了17.1%(P<0.05),其余的力学参数都有减少的趋势;与C组比较,司坦唑醇预防组股骨扭转角度增加了72.5%(P<0.05),其余的力学参数也都有增加的趋势.结论长期使用GC,会使大鼠股骨、腰椎的骨密度和力学性能下降;司坦唑醇则能防止GC所致骨量丢失,还能增加其力学性能.