新活素对急性心肌梗死伴心力衰竭患者炎症因子的影响

摘要

Objective: To explore the effect of rhBNP on inflammatory factors of patients with acute myocardial infarction (AMI) complicating heart failure (HF). Methods; Seventy patients with AMI complicating HF were randomly divided into routine treatment group (n =35) and rhBNP treatment group (n =35). Serum levels of TNF-α,CRP and IL-6 were measured before and after treatment. Echocardiogram indices ( LVEF, LVEDVI, LVESDVI) were recorded before treatment and one month after treatments. Results; Serum levels of TNF-α,CRP and IL-6 decreased significantly after treatment in rhBNP treatment group (P <0. 05) , and they were significantly lower than those in routine treatment group after treatment ( P <0. 05 ) . The improvement of echocardiogram indices was superior in rhBNP group to routine treatment group one month after treatment (P<0.05). Conclusion; rhBNP could alleviate inflammatory injury of myocardium in patients with AMI complicating HF to some extent, and it might improve heart function.%目的:探讨新活素对急性心肌梗死( AMI)伴心力衰竭患者炎症因子的影响.方法:AMI合并心力衰竭患者70例,随机分为常规治疗组(n=35)和新活素治疗组(n=35),分别测定治疗前后血清肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)及白介素-6(IL-6)水平,并记录2组治疗前及治疗后1个月时的左室射血分数(LVEF)、左室舒张末期容积指数( LVEDVI)、左室收缩末期容积指数(LVESDVI).结果:新活素治疗组治疗后血清TNF-α、CRP及IL-6水平较治疗前均明显下降(P＜0.05),且明显低于常规治疗组治疗后(P＜0.05).新活素治疗组治疗后1个月超声心动图相关指标改善优于同期常规治疗组(P＜0.05).结论:新活素能在一定程度上减轻AMI伴心力衰竭患者心肌的炎症反应,改善心功能.