Effect of rosuvastatin on inflammatory factor, oxidative stress and cardiac function in patients with chronic heart failure

摘要

Objective: To explore effect of rosuvastatin on inflammatory factor, oxidative stress andcardiac function in patients with chronic heart failure. Method: A total of 200 cases of patientswith chronic heart failure who were admitted in our hospital from July 2015 to December2016 and were divided randomly into observation group 100 cases and control group 100cases,both groups patients were given conventional treatment of chronic heart failure, observationgroup was given rosuvastatin on this basis. Compared interleukin-6 (IL-6), tumor necrosisfactor-α (TNF-α), hypersensitivity-C reaction protein (hs-CRP), superoxidedismutase(SOD), malondialdehyde (MDA) and cardiac function before and after treatment in twogroups. Results: IL-6, TNF-α, hs-CRP level after treatment was lower than before treatmentin observation group and after treatment in control group. The difference was significant; IL-6,TNF-α, hs-CRP level after treatment was no significant difference with before treatment incontrol group. SOD level was (172.71±5.22) U/mL after treatment in observation group, higherthan before treatment, moreover higher than after treatment in control group; MDA levelwas (3.99±0.31) nmol/mL after treatment in observation group, lower than before treatment,moreover lower than after treatment in control group; there was no significant differencein SOD, MDA level between before and after treatment in control group. After treatment,LVEDD, LVEDF were (52.19±1.33) mm, (36.33±2.82) mm, (59.88±1.62) mm, (42.41±3.43)mm in both groups, all was lower than before treatment, and observation group was lowerthan control group, there was statistical significant difference; LVEF of two groups was(49.90±6.26)%, (42.72±5.14)% respectively after treatment, higher than before treatment, andobservation group was higher than control group, there was statistical significant difference.Conclusion: Rosuvastatin was able to inhibit inflammatory factor, oxidative stress, moreoverimproved cardiac function in patients with chronic heart failure.