Effect of mechanical circulatory support in the heart failure patient with left-right heart failure condition: A simulation study

摘要

Mechanical circulatory support (MCS) is increasingly used in the end-stage heart failure patients. The rotary blood pump (RBP) is a novel technology of MCS that currently used in the left ventricular (LV) failure patient. After RBP implanted in LV, some patient immediately need another RBP on the right side of the heart. The effect of LV-RBP or left ventricular assist device (LVAD) on the right ventricle (RV) has been simulated in both normal RV and pathology RV for education proposes. This simulation was regulated the pathology of the heart from normal heart (Maximum Elastance; Emax: 100%) to pathological heart (E_(max): 50%) and the level of RBP support in the LV (partial support and full support). The result of this simulation showed the hemodynamics during LV-RBP support. The end-diastolic volume of left ventricle was depended on pump speed. The increasing of right ventricular volume during support was showed in the pathological RV. In contrast, the remaining of right ventricular volume during support was showed in the normal RV. In conclusion, this computer simulation can re-generated the hemodynamics and pressure- volume loop heart failure patient with MCS.