Effect of recombinant human brain natriuretic peptide on serum inflammatory factors, neuroendocrine hormones and cardiac function in patients with acute myocardial infarction complicated with heart failure

摘要

Objective: To investigate the effect of recombinant human brain natriuretic peptide (BNP) oninflammatory factors, neuroendocrine hormones and cardiac function indexes in patients withacute myocardial infarction complicated with heart failure. Methods: A total of 91 cases ofacute myocardial infarction with heart failure patients were divided into the control group (n=44)and observation group (n=47) according to the random data table, two groups of patients weregiven conventional treatment, based on this, the control group was given intravenous infusionof Nitroglycerin Injection treatment, the observation group received intravenous injection ofrecombinant human brain natriuretic peptide treatment, compared serum inflammatory factors,neuroendocrine hormone and cardiac function and other indexes of two groups before andafter treatment. Results: there was no significant difference between the two groups beforetreatment. After treatment, the levels of TNF-α, hs-CRP, IL-6, MCP-1, LVESD and LVEDDin the two groups were significantly lower than those within the group before treatment, andthe observation group was significantly lower than the control group; The two groups aftertreatment LVEF levels were significantly higher than those in the group before treatment, andthe observation group was significantly higher than that of control group; the observation groupafter treatment PRA, Ang II and ALD and NE levels were significantly lower than those beforetreatment, and was significantly lower than the control group after treatment, the differencewas significant, PRA, Ang, ALD and NE levels of control group before and after the treatmentwas no significant difference. Conclusion: recombinant human brain natriuretic peptide inthe treatment of acute myocardial infarction with heart failure can effectively reduce the seruminflammatory factors and neuroendocrine hormone levels, improve heart function, and have acertain clinical value.