重组人脑利钠肽治疗对急性心肌梗死伴心力衰竭患者血清炎性因子、神经内分泌激素及心功能的影响

摘要

Objective:To investigate the effect of recombinant human brain natriuretic peptide (BNP) on inflammatory factors,neuroendocrine hormones and cardiac function indexes in patients with acute myocardial infarction complicated with heart failure.Methods:A total of 91 cases of acute myocardial infarction with heart failure patients were divided into the control group (n=44) and observation group (n=47) according to the random data table.Based on conventional treatment,the control group was given intravenous infusion of Nitroglycerin Injection treatment,while the observation group received intravenous injection of recombinant human brain natriuretic peptide treatment.Serum inflammatory factors,neuroendocrine hormone and cardiac function and other indexes of two groups before and after treatment were compared between the two groups.Results:Before treatment,there was no significant difference in detected parameters between the two groups (P>0.05).After treatment,the levels of TNF-α,hs-CRP,IL-6,MCP-1,LVESD and LVEDD in the two groups were significantly lower than that before treatment (P<0.05),and these levels in the observation group were significant lower than that of the control group (P<0.05).After treatment,LVEF levels were significantly higher than those before treatment (P<0.05),and the increase in the observation group was more obvious than that that of control group (P<0.05).After treatment,PRA,Ang II and ALD and NE levels in both groups were significantly lower than those before treatment (P<0.05),and the levels in the observation group was significantly lower than that of the control group (P<0.05).But PRA,Ang,ALD and NE levels of control group showed no significant difference (P>0.05) comparing with that before treatment.Conclusion:Recombinant human brain natriuretic peptide can effectively reduce the serum inflammatory factors and neuroendocrine hormone levels,improve heart function for patients with acute myocardial infarction with heart failure.%目的:探讨重组人脑利钠肽治疗急性心肌梗死伴心力衰竭,对患者血清炎性因子、神经内分泌激素及心功能指标的影响.方法:91例急性心肌梗死伴心力衰竭患者依据随机数据表法分为对照组(n=44)和观察组(n=47),两组均给予常规治疗,在此基础上,对照组给予静脉滴注硝酸甘油注射液治疗,观察组给予静脉滴注重组人脑利钠肽治疗,比较治疗前后两组的血清炎性因子、神经内分泌激素及心功能等指标水平.结果:治疗前两组上述指标水平差异无统计学意义(P>0.05).治疗后,两组TNF-α、hs-CRP、IL-6、MCP-1、LVESD及LVEDD水平较组内治疗前均显著降低(P<0.05),且观察组显著低于对照组(P<0.05);两组治疗后LVEF水平均显著高于组内治疗前(P<0.05),且观察组显著高于对照组(P<0.05);观察组治疗后PRA、AngⅡ、ALD和NE水平显著低于治疗前(P<0.05),且均显著低于对照组治疗后,差异比较有显著性(P<0.05),对照组治疗前后PRA、AngⅡ、ALD和NE水平比较,无明显差异(P>0.05).结论:重组人脑利钠肽治疗急性心肌梗死伴心力衰竭,可有效降低患者的血清炎性因子及神经内分泌激素水平,改善心功能,具有一定的临床价值.