丙泊酚中长链和长链脂肪乳对老年腹腔镜胆囊切除术患者肝功能和免疫功能的影响

摘要

［Objective］To observe the effect of propofol medium- and long-chain fat emulsion on liver function and immune function in elderly patients undergoing laparoscopic cholecystectomy(LC). ［Methods］ Eighty ASA Ⅰ ～ Ⅱ elderly patients undergoing LC were randomly divided into group A and group B with 40 in each.Group A was induced and maintained anesthesia with 1 ％ propofol long-chain fat emulsion injection. Group B was induced and maintained anesthesia with propofol medium-chain fat emulsion injection. ECG, blood pressure and blood oxygen saturation were monitored. The liver function and immune function in patients before and 1h, 24h after surgery were measured. ［Results］ At 24h after surgery, serum alanine aminotransfarase (ALT), aspartate aminotransferase(AST) and total bilirubin(T Bili) in group A were higher than those in group A. Compared with group B, IgG in group A decreased obviously, and the difference was statistically significant( P ＜0. 05). ［Conclusion］Propofol medium-chain fat emulsion has less effect on liver function and immune function in elderly patients undergoing LC, so it is worthy of being extended.%[目的]观察丙泊酚中长链和长链脂肪乳剂对老年腹腔镜胆囊切除术(LC)患者肝功能和免疫功能的影响.[方法]行LC老年患者80例,ASA Ⅰ～Ⅱ级,随机分为A、B两组,每组40人.A组采用1%长链脂肪乳注射液行麻醉诱导和维持.B组采用丙泊酚中/长链脂肪乳注射液行麻醉诱导和维持,常规监测心电图、血压、血氧饱和度.于术前、术后1 h和术后24 h测定肝功能及免疫功能的改变.[结果]B组术后24 h肝功能血清丙氨酸转移酶、天门冬氨酸转移酶、总胆红素低于A组;与B组相比,A组 IgG明显下降,差异均有显著性(P<0.05).[结论]丙泊酚中长链脂肪乳剂对老年LC患者肝功能和免疫的影响小,值得临床推广.