METHOD FOR PREPARING PROPOFOL MEDIUM/LONG CHAIN FAT EMULSION INJECTION

摘要

Disclosed is a method for preparing a propofol medium/long chain fat emulsion injection, the preparation method comprising: under the protection of nitrogen, dissolving glycerin and sodium hydroxide in water for injection, and controlling the aqueous phase temperature at 50ºC-80ºC; and under the protection of nitrogen, dissolving propofol, oleic acid and egg yolk lecithin in an soybean oil and a medium chain triglyceride, heating the oil phase to 50ºC-80ºC, shearing and stirring, and mixing the aqueous phase and the oil phase, shearing same to prepare a primary emulsion, and homogenizing the primary emulsion to obtain a final emulsion. A propofol medium/long chain fat emulsion injection prepared by the method is also disclosed.