甲状腺乳头状癌患者外周血CD4+CD25+Foxp3+调节性T细胞及T-钙粘蛋白的检测及临床意义

摘要

目的 研究CD4 +CD25 +Foxp3 +调节性T细胞(Treg)与T-钙黏蛋白在甲状腺乳头状癌(PTC)外周血中的水平及临床意义.方法 采用回顾性研究方法,选取PTC患者40例(观察组)以及甲状腺腺瘤患者40例(对照组).对比两组患者外周血CD4 +CD25 +Foxp3 +Treg细胞比率及T-钙黏蛋白水平;对比不同病理特征下CD4 +CD25 +Foxp3 +Treg细胞比率及T-钙黏蛋白水平有无差异.结果 PTC组患者CD4 +CD25 +Foxp3 +Treg细胞比率及T-钙黏蛋白水平均明显高于对照组(P <0.05),TNM Ⅲ、Ⅳ期与存在颈部淋巴结转移的PTC患者CD4 +CD25 +Foxp3 +Treg细胞与T-钙黏蛋白水平均明显升高(P <0.05).结论 CD4 +CD25 +Foxp3 +Treg细胞与T-钙黏蛋白可以作为PTC的标志物,同时与患者临床分期以及淋巴结转移有密切的相关性.%Objective To analyze the clinical significance of peripheral blood CD4 +CD25 +Foxp3 +regulatory T cells and T calcium mu-cin detection in thyroid papillary carcinoma patients. Methods 40 cases of PTC patients(observation group)and 40 cases of thyroid adenoma patients(control group)were selected retrospectively. The ratio of CD4 +CD25 +Foxp3 +Treg cells and the level of T calcium mucin in peripheral blood were compared between the two groups,and the difference of CD4 +CD25 +Foxp3 +Treg cell ratio and the level of T calcium mucin between different pathological characteristics were compared. Results CD4 +CD25 +Foxp3 +Treg cells and T calcium mucin levels in PTC patients were significantly higher than those of control group(P <0.05),CD4 +CD25 +Foxp3 +Treg cells and T calcium mucin levels in TNMⅢ,Ⅳperiod patients with cervical lymph node metastasis were significantly higher(P <0.05). Conclusion CD4 +CD25 +Foxp3 +Treg cells with calcium sticky protein can serve as markers of PTC,and at the same time,and these are closely related to clinical stages and lymph node metastasis.