白血病患者血小板输注疗效的影响因素分析

摘要

Objective To investigate the factors affecting platelet transfusion efficiency.Methods A total of 102 cases of leuke-mia patients were recruited in the study,whose platelet count were measured before platelet transfusion and 1,24 h after platelet transfusion,then corrected count increment(CCI)values were calculated.By using CCI combined with clinical manifestations,the ef-ficacy of platelet transfusion were evaluated.The platelet antibody were detected before platelet transfusion.Depending on whether there were platelet antibodies,complications,the number of times of platelet transfusion,the types of platelet,patients were grouped and their platelet transfusion efficiency and CCI values were compared.Results The total effective rate of platelet transfusions were 71.6%(73/102 ).Invalid transfusion group had higher platelet antibody positive rate (17.2%)than effective transfusion group (2.7%),the difference were statistically significant(P <0.05).Among the groups of different transfusion times,the tansfusion effi-ciency was statistically different(P <0.05).With the increase of the number of times of platelet transfusion,the platelet transfusion efficiency decreased.Comparison between different types of platelets showed different platelet transfusion efficiency,which was sta-tistically significant(P <0.05).1 h and 24 h CCI value,platelet antibodies and whether patients with complications were related(P<0.05).1 h and 24 h CCI values were both associated with platelet antibodies and complications(P <0.05).Conclusion Platelet antibodies,complications,times of platelet transfusion and types of platelet transfusion are affecting factors of the transfusion effica-cy in patients with leukemia.%目的：分析影响白血病患者血小板输注疗效的因素。方法共检测102例白血病患者血小板输注前及输注后1、24 h 的血小板计数，计算出血小板校正计数增加值（CCI 值），结合临床表现判断输注疗效。患者输注血小板前进行血小板抗体检测，并根据是否有血小板抗体、并发症、输注次数及输注的血小板种类对患者的血小板输注有效率、CCI 值进行分组比较和统计学分析。结果总血小板输注有效率为71．6％（73／102）。无效组血小板抗体阳性率（17．2％）高于有效组（2．7％），差异有统计学意义（P ＜0．05）。有并发症组血小板输注有效率（52．8％）低于无并发症组（91．8％），差异有统计学意义（P ＜0．05）。随着输注次数增加，血小板输注效率降低。不同血小板输注次数组间输注有效率比较，差异有统计学意义（P ＜0．05）。不同血小板种类间比较，血小板输注效率的差异有统计学意义（P ＜0．05）。1 h 和24 h CCI 值与血小板抗体是否阳性及患者是否有并发症均有关（P ＜0．05）。结论血小板抗体、并发症、输注次数及血小板种类均为白血病患者血小板输注疗效的影响因素。