Platelet factor 4 platelet levels are inversely correlated with steady-state platelet counts and with platelet transfusion needs in pediatric leukemia patients

摘要

Biomarkers of steady-state platelet count and risk for thrombocytopenia postchemotherapy have not been previously identified. Thrombocytopenia can interfere with chemotherapy by limiting doses and delaying therapy [1],potentially resulting in poorer outcomes [2]. Therefore, strategies to predict risk and mitigate chemotherapy-induced thrombocytopenia (CIT) are needed. Additionally, the ability to identify patients at high risk of thrombocytopenia and new strategies to influence platelet production may permit more intensive therapy, while avoiding severe thrombocytopenia and its sequelae.