Objective To discuss the relationship between hepatitis B virus (HBV) genotype and HBV DNA ,liver fibrosis ,liver function and HBeAg .Methods HBV genotypes ,HBV DNA ,liver fibrosis indicators and alanine aminotransferase(ALT ) ,aspartate aminotransferase(AST ) ,total bilirubin(TBIL) ,albumin(ALB) and HBV e antigen(HBeAg) were detected in patients with serum hepatitis .All data were statistically analyzed .Results There was no significant difference of HBV DNA ,ALT ,AST ,TBIL ,ALB , procollagen- Ⅲ -peptide ,type Ⅳ collagen ,hyaluronic acid and laminin between patients with B and C genotype infection (P> 0 .05) . However ,HBeAg level in patients with C genotype infection was higher than that in patients with B genotype infection (P< 0 .05) . Conclusion There might be no significant difference of HBV DNA ,liver function and liver fibrosis between patients with B and C genotype infection ,but HBeAg level in patients with C genotype infection could be higher than patients with B genotype infection .%目的：探讨 HBV 基因型和 HBV DNA 、肝纤维化指标、肝功能指标及 HBV e 抗原（HBeAg ）的相关性。方法对乙型肝炎患者进行 HBV 基因型、HBV DNA 、肝纤维化四项指标、丙氨酸氨基转移酶（ALT ）、天门冬氨酸氨基转移酶（AST ）、总胆红素（TBIL）、清蛋白（ALB）、HBeAg 检测。对检测结果进行统计学分析。结果 B 、C 型 HBV 感染者间 HBV DNA 、ALT 、AST 、TBIL 、ALB 、Ⅲ型前胶原肽、Ⅳ型胶原、透明质酸、层粘连蛋白水平比较差异无统计学意义（P ＞0．05）。 C 型 HBV 感染者 HBeAg水平高于 B 型 HBV 感染者（P＜0．05）。结论 C 型和 B 型 HBV 感染者间 HBV DNA 、肝功能指标、肝纤维化指标水平无差异，但 C 型 HBV 感染者 HBeAg 水平高于 B 型 HBV 感染者。
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