文拉法辛联合认知行为疗法治疗帕金森抑郁

摘要

目的 研究文拉法辛联合认知行为疗法治疗帕金森抑郁的疗效.方法 将70例帕金森抑郁患者随机分为研究组（采用文拉法辛联合认知行为疗法治疗）和对照组（单用文拉法辛治疗）,各35例,于治疗前及治疗后第4、8周末采用汉密顿抑郁量表(HAMD,17项)评定抑郁程度.结果 两组治疗4、8周后HAMD评分均低于治疗前(P＜0.05),第4、8周末,研究组的HAMD均低于同期对照组,差异均有统计学意义(P＜0.05).结论 文拉法辛联合认知行为疗法治疗帕金森抑郁疗效确切,比单用文拉法辛治疗效果更好.%Objective To determine whether Venlafaxine combined with cognitive-behavioral therapy (CBT) is effective in the treatment of depression in Parkinson's disease (PD). Methods A total of 70 patients with PD were randomly assigned into the study group(treated by venlafaxine combined with CBT) and the control group (treated with venlafaxine alone). Before treatment and on the forth and eighth weekend after treatment, Hamilton Depression Scale (HAMD, 17 items) was used to evaluate the degree of depression. Results On the forth and eighth weekend after the treatment, the mean HAMD in the two groups were significantly lower than those before treatment (P<0.05), and the HAMD was significantly lower in the study group than those in the control group (P<0.05). Conclusion Venlafaxine combined with CBT is more effective than venlafaxine alone in the treatment of depression in Parkinson's disease.