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COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR THE SELECTIVE ACTIVATION / STIMULATION OF A-7 NICOTINIC RECEPTORS IN A PATIENT, METHOD FOR THE TREATMENT OF A PATIENT SUFFERING FROM A PSYCHOTIC DISEASE, A DISEASES AND A NEURODEGENERATIVE DISEASE. OR A CONDITION OF DEGENERATION OF MEMORY AND / OR COGNITION, METHOD FOR THE TREATMENT OF A PATIENT SUFFERING FROM DEMENTIA AND / OR ANOTHER CONDITION WITH LOSS OF MEMORY, METHOD FOR TREATING A PATIENT SUFFERING DEGENERATION OF DEATH MEMORY SOFT COGNITIVE DEGENERATION DUE TO AGING, ALZHEIMER EVIL, SCHIZOPHRENIA, PARKINSON EVIL, HUNTINGTON EVIL, PICK EVIL, CREUTZFELDT-JAKOB EVIL, DEPRESSION, AGING, SICKNESS, HARMONY, HARMONY, ACCIDENT, HEALTH, HEALTH MULTIINFARTO DEMENTIA, HIV AND / OR CARDIOVASCULAR DISEASE, METHOD FOR TREATING AND / OR PREVENTING DEMENTIA IN A PATIENT WITH ALZHEIMER'S EVIL , METHOD FOR THE TREATMENT OF A PATIENT FOR THE WITHDRAWAL OF ALCOHOL OR FOR THE TREATMENT OF A PATIENT WITH ANTI-TOXIC THERAPY, METHOD FOR THE TREATMENT OF

机译:化合物,药物组合物,患者中A-7烟碱受体选择性激活/刺激的方法,患有精神疾病,疾病和神经退行性疾病的患者的治疗方法。或记忆退化和/或认知状况,治疗患有痴呆的患者和/或记忆丧失的其他状况的方法,治疗因衰老而导致死亡的记忆性软凝集性退化的患者的方法,以及恶性,精神分裂症,帕金森病,亨廷顿病,匹克病,CREUTZFELDT-雅各布病,抑郁症,衰老,疾病,病态,和谐,和谐,事故,健康,多发性痴呆病,HIV和/或疾病或方法老年痴呆症患者中的痴呆症,戒断酒精或治疗患者的方法,抗病毒治疗,治疗方法

摘要

COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR THE SELECTIVE ACTIVATION / STIMULATION OF A-7 NICOTINIC RECEPTORS IN A PATIENT, METHOD FOR THE TREATMENT OF A PATIENT SUFFERING FROM A PSYCHOTIC DISEASE, A DISEASES AND A NEURODEGENERATIVE DISEASE. OR A CONDITION OF DEGENERATION OF MEMORY AND / OR COGNITION, METHOD FOR THE TREATMENT OF A PATIENT SUFFERING FROM DEMENTIA AND / OR ANOTHER CONDITION WITH LOSS OF MEMORY, METHOD FOR TREATING A PATIENT SUFFERING DEGENERATION OF DEATH MEMORY SOFT COGNITIVE DEGENERATION DUE TO AGING, ALZHEIMER'S EVIL, SCHIZOPHRENIA, PARKINSON'S EVIL, HUNTINGTON'S EVIL, PICK'S EVENT, CREUTZFELDT-JAKOB EVIL, DEPRESSION, AGING, SICKNESS, HARMONY, HARMONY, ACCIDENT, HEALTH, HEALTH MULTIINFARTO DEMENTIA, HIV AND / OR CARDIOVASCULAR DISEASE, METHOD FOR TREATING AND / OR PREVENTING DEMENTIA IN A PATIENT WITH ALZHEIMER'S EVIL , METHOD FOR THE TREATMENT OF A PATIENT FOR THE WITHDRAWAL OF ALCOHOL OR FOR THE TREATMENT OF A PATIENT WITH ANTI-TOXIC THERAPY, METHOD FOR THE TREATMENT OF A PATIENT TO CONFIRM NEUROPROTECTION AGAINST DAMAGE ASSOCIATED WITH CEREBRAL EARLY ACCIDENT RESULTS GLUTAMATE, METHOD FOR THE TREATMENT OF A PATIENT SUFFERING FROM NICOTIN ADDICTION, PAIN, TIME DIFFERENCE, OBESITY AND / OR DIABETES, METHOD OF INDUCING A PATIENT TO STOP SMOKING, METHOD FOR TREATING A PATIENT WHO SUFFERS SOFT COGNITIVE DEGENERATION (MCI), VASCULAR DEMENTIA (VAD), COGNITIVE DECLINATION ASSOCIATED WITH AGE (AACD), AMNESIA ASSOCIATED WITH OPEN HEART SURGERY, CARDIAC APPROPRIATION, GENERAL ANESTHESIA, DEHESIA, DEHESIA, HOSPITAL SLEEP INDUCED BY COGNITIVE DEGENERATION, CHRONIC FATIGUE SYNDROME, NARCOLEPSY, AIDS-RELATED DEMENTIA, RELATED COGNITIVE DEGENERATION OF WITH EPILEPSY, DOWN SYNDROME, DEMENTIA RELATED TO ALCOHOLISM, DRUG / SUBSTANCES-DEGENERATION, PUGILISTIC DEMENTIA (BOXEATER SYNDROME), OR ANIMAL DEMENTIA, METHOD FOR TREATING TREATMENT TREATMENT METHOD A PATIENT SUFFERING FROM MEMORY DEGENERATION, METHOD FOR THE TREATMENT OR PROPHYLAXIS OF A DISEASE OR A CONDITION RESULTING FROM THE DISCURSION OF THE TRANSMISSION OF THE NICOTINIC ACETYLINE RECEPTOR IN A PATIENT, METHOD FOR THE TREATMENT OR A PROFILE OF PROFILE RESULTING FROM DEFECTIVE ACETYL CHILLINE NICOTINIC RECEPTORS OR MALFUNCTIONING IN A PATIENT, METHOD FOR TREATING OR PROPHYLAXIS OF A DISEASE OR A CONDITION RESULTING FROM THE DELETED TRANSMISSION OF THE ACETYLINE COLIN RECEIVER TO A NICOTYLINIC TREATMENT INTO A NICOTINIC TREATMENT OR A NICOTININE TREATMENT. A DISEASE OR CONDITION RESULTING FROM THE LOSS OF CHOLINERGIC SYNOPSIS IN A PATIENT, METHOD O FOR THE PROTECTION OF NEURONES IN A PATIENT WITH NEUROTOXICITY INDUCED BY THE ACTIVATION OF A7NACH RECEPTORS, METHOD FOR THE TREATMENT OR PROPHYLAXIS OF A NEURODEGENERATIVE DISORDER THROUGH THE INHIBITION OF THE PEEPIDE CONTAINED WITH AEPETHESIS OF AEPHESIS OF AEPHESIS OF AEPHESIS OF AEPHESIS. TREATMENT OF A PATIENT SUFFERING FROM AN INFLAMMATORY DISEASE The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), the activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetyl choline receptors, especially in the brain. In addition, the present invention relates to new compounds (for example, indazoles and benzothiazoles), which act as ligands for the cx7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of using them.
机译:化合物,药物组合物,患者中A-7烟碱受体选择性激活/刺激的方法,患有精神疾病,疾病和神经退行性疾病的患者的治疗方法。或记忆退化和/或认知状况,治疗患有痴呆的患者的方法和/或记忆丧失的其他状况,治疗因衰老而导致死亡的记忆性软凝集性退化的患者的方法,以及病,精神分裂症,帕金森病,亨廷顿病,Pick病,CREUTZFELDT-Jakob病,抑郁,衰老,病态,和谐,和谐,意外,健康,健康,多发性糖尿病,艾滋病和/或方法老年痴呆症患者中的痴呆症,一种用于戒断酒精或治疗患者的抗毒疗法的方法,一种用于治疗伴有神经损伤的患者的治疗方法。结果谷氨酸盐,治疗尼古丁成瘾,疼痛,时差,肥胖和/或糖尿病,甲烷的患者的方法诱发患者停止吸烟的OD,治疗患者的方法,软性认知功能退化(MCI),血管性痴呆(VAD),年龄相关的认知功能下降(AACD),伴有开放式心脏手术的健忘症,心律失常,DEHESIA,DEHESIA,认知退化引起的医院睡眠,慢性疲劳综合征,麻醉,与艾滋病有关的痴呆,与癫痫相关的认知退化,唐氏综合症,与老年痴呆症相关的痴呆症,老年痴呆症(与酒精有关)或动物痴呆,一种治疗方法,一种因记忆退化而患的患者,一种因疾病或疾病的传播而受到困扰的疾病或病情的治疗或预防方法,或患者的乙酰乙酰胆碱烟碱受体衰弱或患者失灵导致的患者档案,用于治疗或预防由乙炔考林接收器向新烟碱治疗的传播到新烟碱治疗或烟碱治疗而引起的疾病或状况的治疗或预防。因患者胆碱能丧失而引起的疾病或状况,通过O7受体活化引起的具有神经毒性的患者中保护神经元的方法O,用于治疗或预防神经退行性神经变性的方法肽包含有无症状的无症状,无症状的无症状的无症状。感染性疾病的患者的治疗技术领域本发明总体上涉及烟碱型乙酰胆碱受体(nACh受体)的配体,nACh受体的活化以及与烟碱型乙酰胆碱受体缺陷或功能障碍有关的疾病状况的治疗,特别是在大脑中。另外,本发明涉及充当cx7 nACh受体亚型的配体的新化合物(例如,吲唑和苯并噻唑),制备此类化合物的方法,包含此类化合物的组合物以及使用它们的方法。

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