目的：探讨文拉法辛联合认知行为疗法治疗帕金森症合并抑郁、认知功能障碍的临床疗效。方法选择58例帕金森症合并抑郁患者，根据治疗方法分为联合组和对照组。对照组给予文拉法辛胶囊口服治疗，联合组在此基础上给予认知行为疗法，比较两组患者的临床疗效。结果两组组内比较，治疗后焦虑、抑郁评分显著下降（P＜0.01），治疗后两组组间比较，联合组评分显著低于对照组（P＜0.01）。联合组在干预后认知功能总分、视空间与执行能力、命名能力、语言能力、延迟回忆以及定向力评分显著高于对照组（P＜0.01）。结论文拉法辛联合认知行为干预治疗帕金森症合并抑郁、认知功能障碍，具有较好的临床疗效，能够显著改善患者焦虑、抑郁、认知功能障碍等情况。%Objective To discuss clinical efficacy of venlafaxine combined with cognitive behavioral intervention for Parkinson's disease with depression and cognitive dysfunction. Methods 58 cases of Parkinson's disease with depression and cognitive dysfunction were selected, and they were divided into combination group and control group according to treatment methods. Control group was treated by venlafaxine treatment. Combination group was treated by venlafaxine combined with cognitive behavioral intervention treatment. Clinical efficacy of two groups were compared. Results After treatment, HAMA and HAMD scores of two groups decreased apparently(P<0.01). HAMA and HAMD scores of combination group after treatment were lower than those of control group(P < 0.01). Cognitive function scores, depending on space and ability to execute, naming ability, language ability, delayed recall and disorientation ratings of combination group after treatment were higher than those of control group(P<0.01). Conclusion Venlafaxine combined with cognitive behavioral intervention for Parkinson's disease with depression and cognitive dysfunction shows better clinical efficacy, relieves depression and anxiety, and improves cognitive function.
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