建立高效液相色谱-串联质谱结合加速溶剂萃取测定食品用纸容器中全氟辛酸的方法。样品用甲醇作为溶剂进行快速溶剂萃取。萃取液经C18固相萃取柱富集净化后，以C18柱为分离柱，以甲醇、水为流动相，梯度洗脱，电喷雾负离子模式下多反应监测模式检测。全氟辛酸在0.5～50ng/mL范围内线性良好(R2=0.9993)，回收率为90.2%～103.3%，相对标准偏差为2.74%～6.03%，检出限为0.1μg/kg(RSN=3)。该方法操作简便，灵敏度高，适用于食品用纸容器中全氟辛酸及其盐类残留分析。%High performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) with accelerated solvent extraction (ASE) was used to establish a method for quantitative detection of perlfuorooctanoic acid (PFOA) in paper food containers. Samples were extracted by ASE method with methanol. The resulting extract was cleaned up using a C18 solid phase extraction (SPE) column, and separate on a chromatographic C18 column using methanol and deionized water as mobile phases by gradient elution. Instrumental analysis was performed by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in the multiple-reaction monitoring (MRM) mode. The developed calibration curve was linear in the range of 0.5–50 ng/mL with a correlation coefifcient (r2) of 0.9993. The recovery rates for PFOA were in the range of 90.2%–103.3%with relative standard deviations of 2.74%–6.03%. The detection limit (RSN=3) was 0.1 µg/kg. This method was easy, time-saving, sensitive and suitable for the determination the PFOA in paper foods containers.
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