S-腺苷蛋氨酸对微生物次生代谢产物的调控作用与机制研究进展

摘要

S-Adenosylmethionine (SAM) , an activity substance in living organisms, is generally known as a biological methyl donor in reactions catalyzed by methyltransferases.SAM can also provide group sources including sulfur groups, amino groups and ribosyl groups in many biosynthetic processes.Moreover, SAM is used as signal molecule to regulate metabolism in microorganism.The minor change of SAM concentration in the cells can result in a significant affections on the synthesis of microbial secondary metabolites and cell differentiation This review described the metabolic pathways of SAM in organism and relative genes as well as the regulation mechanism on the microbial secondary metabolites.%S-腺苷蛋氨酸是生物体内一种非常重要的生理活性物质,除主要作为甲基供体和参与众多转硫基、转氨基和转核糖基等重要的生化反应,还能作为信号分子调控微生物的代谢.当细胞内S-腺苷蛋氨酸浓度发生微小变化时,就可以对微生物细胞代谢产物的合成以及细胞分化产生较大的影响.文中就S-腺苷蛋氨酸在生物体内的循环途径、相关基因以及近年来S-腺苷蛋氨酸对微生物次级代谢的调控作用和调控机制进行了综述.