敲低miR-221、miR-222表达对乳腺癌细胞放射敏感性影响的研究

摘要

cells, the expression of PTEN was up-regulated while pAkt down-regulated. Conclusions AS-miR-221 and AS-miR-222 may enhance the radiosensitivity of MCF-7 breast cancer cells by up-regulating the expression of PTEN.%R-222共转染组细胞PTEN蛋白表达明显上调,pAkt蛋白表达下调.结论 反义miR-221、AS-miR-222可能通过上调PTEN蛋白表达增强MCF-7人乳腺癌细胞放射敏感性.