自噬在多柔比星所致心脏毒性中的作用研究进展

摘要

多柔比星是一种广谱高效的抗肿瘤药物,但其心脏毒性是限制其临床应用的主要原因之一.多柔比星致心脏毒性的机制尚不完全清楚,通常认为与活性氧增加、线粒体损伤和细胞凋亡等机制相关.细胞自噬是一类依赖于溶酶体的蛋白质降解途径.近年来大量研究证实,自噬在多柔比星所致心脏毒性中具有重要作用.本文主要回顾自噬在多柔比星所致心脏毒性中的作用.%Doxorubicin (Dox) is an effective wide-spectrum antitumor drug. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanisms of cardiotoxicity have not been clearly elucidated, but are known to involve oxidative stress, mitochondrial dysfunction and apoptosis. Autophagy is a lysosome-dependent protein degradation pathway. More recently, many studies have suggested that autophagy plays an important role in Dox-induced cardiotoxicity. This paper gives a systematic review of the role of autophagy in Dox-induced cardiotoxicity.