Compound pharmaceutical compound and processes to antagonize endothelin to treat hypertension congestive heart failure restenosis following arterial lesion cerebral or myocardial ischemia or atherosclerosis coronary angina cerebral vasospasm acute renal failure and chronic gastric ulceration cyclosporine-induced nephrotic toxicity endotoxin-induced endotoxin-induced toxicity by endotoxin with lpl proliferative diseases acute pulmonary hypertension or chronic platelet aggregation tombose cardiotoxicity mediated by il-2 nonciception colitis disorder of vascular permeabulity lesion by reperfusion-ischemia deraynaud disease and migraine and to prepare a compound.

摘要

A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.