首页> 外国专利> compound for use in the manufacture of a medicament for reducing the symptoms of a disease selected from the group consisting of muscular dystrophy, arthritis, craniocerebral trauma, spinal cord injury, sepsis, rheumatic disease, cancer atherosclerosis, type 1 diabetes, type 2 diabetes, leptospirosis kidney disease, glaucoma, retinal disease, aging, headache, aches, complex regional pain syndrome, cardiac hypertrophy, muscle wasting, catabolic disorders, obesity, fetal growth retardation, hypercholesterolemia, heart disease, chronic heart failure, ischemia / reperfusion, stroke, cerebral aneurysm, angina pectoris, lung disease, cystic fibrosis, acid-induced lung injury, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, sjogren's syndrome, hyaline membrane disease, kidney disease, glomerular disease, liver disease alcohol, bowel diseases, peritoneal endometriosis, skin diseases and, nasal sinusitis, mesothelioma, anhidrotic ecodermal dysplasia-id, behcet's disease,

compound for use in the manufacture of a medicament for reducing the symptoms of a disease selected from the group consisting of muscular dystrophy, arthritis, craniocerebral trauma, spinal cord injury, sepsis, rheumatic disease, cancer atherosclerosis, type 1 diabetes, type 2 diabetes, leptospirosis kidney disease, glaucoma, retinal disease, aging, headache, aches, complex regional pain syndrome, cardiac hypertrophy, muscle wasting, catabolic disorders, obesity, fetal growth retardation, hypercholesterolemia, heart disease, chronic heart failure, ischemia / reperfusion, stroke, cerebral aneurysm, angina pectoris, lung disease, cystic fibrosis, acid-induced lung injury, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, sjogren's syndrome, hyaline membrane disease, kidney disease, glomerular disease, liver disease alcohol, bowel diseases, peritoneal endometriosis, skin diseases and, nasal sinusitis, mesothelioma, anhidrotic ecodermal dysplasia-id, behcet's disease,

机译:用于制造减轻疾病症状的药物的化合物,所述疾病选自肌肉营养不良,关节炎,颅脑外伤,脊髓损伤,败血症,风湿性疾病,癌症动脉粥样硬化,1型糖尿病,2型糖尿病,钩端螺旋体病肾脏疾病,青光眼,视网膜疾病,衰老,头痛,疼痛,复杂的局部疼痛综合征,心脏肥大,肌肉消瘦,分解代谢异常,肥胖,胎儿发育迟缓,高胆固醇血症,心脏病,慢性心力衰竭,缺血/再灌注,中风,脑动脉瘤,心绞痛,肺部疾病,囊性纤维化,酸引起的肺损伤,肺动脉高压,哮喘,慢性阻塞性肺疾病,干燥综合征,透明膜疾病,肾脏疾病,肾小球疾病,酒精中毒,肠病,腹膜子宫内膜异位症,皮肤疾病和鼻窦炎,间皮瘤,缺汗的生态皮肤异型增生,白塞病,

摘要

The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-ºB for the treatment or prevention of muscular wasting disease, including muscular dystrophy.
机译:本发明涉及化合物和方法,其可用于治疗神经肌肉疾病如肌营养不良症,并可用作NF-κB抑制剂以治疗或预防包括肌肉营养不良症在内的肌肉萎缩疾病。

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