奥曲肽对大鼠急性坏死性胰腺炎血液中前列腺素水平的调节作用

摘要

Objective　To explore causes for microcirculatory disorder after acute necrotizing pancreatitis (ANP) and further clarify mechanism of treatment of ANP by Octreotide. Methods　Twenty-four rats were equally randomized into the control group, ANP group and Octreotide-treated group. The blood levels of TXB2, PGI2 and PGE2 were measured in all the 3 groups. Results　The blood level of TXB2 significantly increased, that of PGI2 remarkably decreased and that of PGE2 remained unchanged in ANP group as compared with the control. In the Octreotide-treated group, the blood level of TXB2 significantly decreased, that of PGI2 markedly increased and that of PGE2 remained unchanged. Results　Octreotide can improve the prognosis of ANP by regulating blood levels of TXB2 and PGI2 and increasing the ratio of PGI2/TXB2 to ameliorate microcirculation of organs, especially the pancreas.%目的　探讨急性坏死性胰腺炎(ANP)胰腺微循环血供障碍的原因,进一步阐明奥曲肽治疗ANP的可能机制。方法　实验研究分A、B、C 3组，每组8只大鼠，共24只，随机分组。A组:空白对照组;B组:ANP模型组；C组：奥曲肽治疗组。分别测定每组血液中TXB2、PGI2及PGE2含量。结果　实验性急性坏死性胰腺炎早期(2 h),血液中TXB2含量显著升高,PGI2则显著降低,PGE2无显著变化。使用奥曲肽治疗ANP后,其血液中TXB2显著降低,PGI2显著升高,PGE2无显著变化。结论　奥曲肽可能通过改变ANP血液中TXB2、PGI2水平，升高PGI2及TXB2比值,从而改善全身各脏器，特别是胰腺组织微循环血供,改善病变脏器的预后。