Objective To investigate whether anger emotion is the risk factor of Alzheimer's disease (AD) , and for the long-term accumulation of anger can accelerate the aging brain to provide epidemiological basis. Methods AD patients were selected as case groups, the controls without dementia, depression, a history of neurological or psychiatric illness were selected as normal control groups in hospital or community, according to the same sex, same age ( ± 3 years) , and the same educational level, proceeded 1:1 matched the case-control study. Survey method was face to face interviews. Results Trait anger of AD patients scored significantly higher than that of normal control group ( P < 0. 01). Compared with normal control group, high trait anger individuals risk of AD was significantly higher than that of low trait anger individuals (P<0. 01). The OR value (95%CI) was 51. 857 (14. 009, 191. 954). AD patients with anger expression (AX-0, AX-I) was significantly higher than that of normal control group ( P < 0. 01) , and anger control ( AC-0, AC-I) was significantly lower than that of normal control group ( P < 0. 01) , AD patients with anger expression index was significantly higher than that of normal control group ( P < 0. 01). Conclusions Anger emotion is associated with AD, high trait anger is the risk factor of AD. AD patients are more likely to tendency or character of anger expression-out or anger expression-in, they have the high level of anger expression and low controlled anger.%目的 探讨愤怒情志与阿尔茨海默病(AD)的病因学关系,为愤怒长期积累可加速脑老化的论断提供流行病学依据.方法 选取AD患者作为病例,以医院或社区无痴呆病、抑郁症等神经或精神疾病史者为对照,按同性别、同年龄段(±3岁)、同文化程度进行1∶1匹配的病例对照研究.调查方式为面对面访谈.结果 AD患者特质怒得分明显高于正常对照组(P＜0.01)；与正常对照组相比,高特质怒个体AD发病风险明显高于低特质怒个体(P＜0.01),OR值(95％ CI)为51.857( 14.009,191.954)；AD患者怒的表达(AX-O、AX-I)显著高于正常对照组(P＜0.O1),而怒的控制( AC-O、AC-I)显著低于正常对照组(P＜0.01),AD患者怒表达指数显著高于正常对照组(P＜0.01).结论 愤怒情志与AD发病相关,高特质怒是AD发病的危险因素；与正常人群相比,AD患者具有容易发怒或郁怒的倾向或特质,怒的表达程度高而控制力较弱.
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