antibody that specifically binds to rage; chimeric antibody or a rage binding fragment thereof; humanized antibody or a rage binding fragment thereof; humanized antibody that specifically binds to rage or a rage binding fragment thereof; antibody that specifically binds to rage and blocks the binding of a rage body partner; isolated nucleic acid; method of treating an individual who has a rage-related disease or disorder; method of treating sepsis or septic shock in a human subject; method of treating systemic listeriosis in a human subject; and method of inhibiting the binding of a rage binding partner (rage-bp), rage in a mammalian subject

摘要

ANTIBODY THAT SPECIFICALLY LINKS TO RAGE; CHEMICAL ANTIBODY OR A DOMESTIC RAGE BINDING FRAGMENT; HUMANIZED ANTIBODY OR A RAGE BINDING FRAGMENT OF THE SAME; HUMANIZED ANTIBODY THAT SPECIFICALLY LINKS TO RAGE OR A RAGE BINDING FRAGMENT OF THE SAME; ANTIBODY THAT SPECIFICALLY LINKS TO RAGE AND BLOCKS THE LINK OF A RAGE BODY PARTNER; ISOLATED NUCLEIC ACID; METHOD OF TREATING AN INDIVIDUAL WHO HAS A RAGE-RELATED DISEASE OR DISORDER; METHOD OF TREATING SEPTIC OUCHOQUE SEPTIC IN A HUMAN INDIVIDUAL; METHOD OF TREATING SYSTEMIC LISTERIOSIS IN A HUMAN INDIVIDUAL; AND METHOD OF INHIBITING THE BINDING OF A RAGE BINDING PARTNER (RAGE-BP), RAGE IN A MAMMALIAN INDIVIDUAL These are antibodies that specifically bind to the receptor for advanced glycation end products (RAGE) and RAGE binding fragments from same. Pharmaceutical compositions comprising such anti-RAGE antibodies and fragments of RAGE-binding antibody thereof have also been described and their use for the treatment of RAGE-related diseases.