成骨细胞在维持机体糖稳态中调节作用的研究

摘要

成骨细胞特异性表达的ESP基因通过控制骨钙素的生物活性来参与对糖稳态的调节,其ESP基因缺陷可以保护小鼠免于发生糖尿病和肥胖;成骨细胞交感神经通路是瘦素调节胰岛素分泌的主要机制,揭示了成骨细胞在维持机体糖稳态中的重要作用.%ESP is an osteoblasts-specificity gene. It can control the activation of osteocalcin to partake the regulation of glucose metabolism. Osteoblast ESP gene deficiency protects mice from incidence of diabetes and obesity. Leptin-dependent sympathetic suppression of insulin secretion occurs through the osteoblasts. Conversely, osteocalcin, an osteoblast-derived signaling molecule, regulates glucose metabolism resulting in increased insulin secretion and sensitivity. Osteoblast plays a very important role in maintaining glucose homeostatsis.