针对不同靶点新型抗结核药物的药效和药动学性质研究

摘要

Tuberculosis,as the most significant infectious disease seriously threatening the human health,has worldwide reappeared in recent years.With the increase of multi-drug resistant strains,the current anti-TB drugs can no longer meet the requirements of clinical therapy.The research and development of new anti-TB drugs has been extremely urgent.This paper summarized the pharmacokinetics and pharmacodynamics of new anti-TB drug candidates for different targets,which are in clinical or preclinical studies.This will provide a reference to the future development ofanti-TB drugs.%结核病作为危害人类健康最重大的传染病,近年来在全球范围内又死灰复燃.随着多药耐药菌株的不断增加,原有的抗结核药物己不能满足临床的治疗要求,新型抗结核药物的研发迫在眉睫.本文选取了最新进入临床研究或临床前研究的抗结核候选药物,按照其不同的作用靶点综述了各个药物的药效学及药动学性质,为今后抗结核药物的研发提供参考和依据.