经皮冠状动脉介入术中冠脉应用替罗非班临床评价

摘要

目的 探讨心肌梗死(MI)患者经皮冠状动脉介入术(PCI术)中冠脉应用替罗非班后心肌灌注程度及其对心功能的影响.方法 选取2014年2月至2016年3月医院行PCI术的MI患者76例,PCI术中均冠脉应用替罗非班,术后均接受彩色多普勒超声检查.将心肌灌注Ⅰ级及Ⅱ级者42例纳入研究组,心肌灌注0级者34例纳入对照组,对比两组心功能指标.结果 术后7 d及3个月,研究组左心室射血分数(LVEF)、左心室排血量(CO)、每搏输出量(SV)、心指数(CI)、室间隔收缩率、左室短轴缩短率、心肌做功指数(Tei指数)均明显大于对照组(P<0.05).结论 MI患者PCI术中冠脉应用替罗非班有助于提高心肌灌注程度,且心肌灌注程度与心功能呈正相关.%Objective To investigate the effect of tirofiban on the degree of myocardial perfusion and cardiac function after percutaneous coronary intervention(PCI)in patients with myocardial infarction(MI). Methods Totally 76 patients with MI underwent PCI in the hospital from February 2014 to March 2016 were selected,all patients were treated with tirofiban during PCI,and all patients underwent color doppler ultrasonography after operation. 42 patients with myocardial perfusion Ⅰand Ⅱwere enrolled in the study group,and 34 patients with myocardial perfusion grade 0 were enrolled in the control group. The cardiac function indexes of the two groups were compared. Results 7 d and 3 months after operation, the LVEF,CO,SV,CI,ventricular septal shortening,left ventricular short axis shortening rate and Tei index in the study group were significantly higher than those in the control group( P < 0. 05). Conclusion The appli-cation of tirofiban in patients with MI during PCI is helpful to improve the degree of myocardial perfusion,and the degree of my-ocardial perfusion is positively correlated with cardiac function.