蛋白乙酰化在基因组稳定性维护中发挥重要作用

摘要

The level of histone acetylation affects the chromatin structure directly.With the optimal chromatin struc-ture genetic material is successfully and completely copied,which ensures the high fidelity of genetic material be-tween different generations and is a key determinant of genome stability.A large number of studies have shown that the role of protein acetylation is much more complex.Histone acetylation not only affects the transfer and expression of genetic material,but also with the non-histone acetylation plays an important role in the DNA damage and repair at the same time.This review introduces numerous examples of histone and non-histone acetylation and illustrates the mechanism of their effects on maintaining genome integrity and chromosome stability in detail.%组蛋白的乙酰化水平直接影响着染色质结构,使它表现出最适物理化学特性,从而保证着遗传物质顺利地被复制.遗传物质只有顺利完整地被复制,生物同一种族间遗传物质才会在数量上高度稳定,生物种族才得以延续.然而目前大量研究已经表明蛋白乙酰化还包括大量非组蛋白乙酰化,还有许多更为复杂的作用.它们不仅仅影响着遗传物质的传递和表达,还在DNA损伤修复中发挥重要作用.该文综述列举了大量组蛋白和非组蛋白乙酰化的例子,并通过这些例子详细阐述了蛋白乙酰化在保持基因组稳定中发挥作用的机制.