首页> 外国专利> Antibody, hybridoma, transfectome, eukaryotic or prokaryotic host cell, non-human animal or transgenic plant, composition, immunoconjugate, bispecific molecule, kit, expression vector and methods of producing a human monoclonal antibody, inhibiting growth of a cell expressing cd20, killing a cd20 expressing cell, treating or preventing a disease, and detecting the presence of cd20 antigen or a cd20 expressing cell in a sample and cd20 antigen or a cd20 expressing cell in a patient

Antibody, hybridoma, transfectome, eukaryotic or prokaryotic host cell, non-human animal or transgenic plant, composition, immunoconjugate, bispecific molecule, kit, expression vector and methods of producing a human monoclonal antibody, inhibiting growth of a cell expressing cd20, killing a cd20 expressing cell, treating or preventing a disease, and detecting the presence of cd20 antigen or a cd20 expressing cell in a sample and cd20 antigen or a cd20 expressing cell in a patient

机译:抗体,杂交瘤,转染子,真核或原核宿主细胞,非人类动物或转基因植物,组合物,免疫缀合物,双特异性分子,试剂盒,表达载体和产生人类单克隆抗体的方法,可抑制表达cd20的细胞的生长,杀死小鼠cd20表达细胞,治疗或预防疾病,并检测样品中cd20抗原或cd20表达细胞和患者中cd20抗原或cd20表达细胞的存在

摘要

"ANTIBODY HYBRIDOMA, transfectoma, host cell eukaryotic or prokaryotic, NOT HUMAN ANIMAL OR PLANT GM, COMPOSITION immunoconjugate molecule bispecific, KIT, EXPRESSION VECTOR AND PRODUCE METHODS A MONOCLONAL HUMAN, to inhibit A GROWTH cell expressing CD20, KILLING A CD20 EXPRESSING CELL TO TREAT OR PREVENT A DISEASE AND DETECTING THE PRESENCE OF CD20 ANTIGEN OR A CD20 EXPRESSING CELL IN AN SAMPLE AND ANTIGEN CD20 IN A PATIENT ". Isolated human monoclonal antibodies that bind to and inhibit human CD20 and related antibody-based compositions and molecules are disclosed. Human antibodies may be produced by a transfectome or a non-human transgenic animal, for example a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising human antibodies, non-human transgenic animals and hybridomas producing human antibodies, and therapeutic and diagnostic methods for using human antibodies.
机译:“抗体杂交瘤,转染瘤,真核或原核宿主细胞,不是人类动物或植物基因改造的GM,组成免疫共轭分子双特异性,试剂盒,表达载体和生产方法的单克隆,可抑制表达CD20的生长细胞,杀死表达CD20的细胞或预防疾病并检测样品中CD20抗原或CD20表达细胞的存在,而患者中CD20抗原的存在。公开了结合并抑制人CD20的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。人抗体可以由转染子或非人转基因动物,例如转基因小鼠产生,其能够产生经历V-D-J重组和同种型转换的人单克隆抗体的多种同种型。还公开了包含人抗体,产生人抗体的非人转基因动物和杂交瘤的药物组合物,以及使用人抗体的治疗和诊断方法。

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