Isolated human antibody, hybridoma, transfectoma, eukaryotic or prokaryotic host cell, non-human animal or transgenic plant, method for producing a human monoclonal antibody, composition, immunoconjugate, bispecific or multispecific molecule, method for inhibiting the development and / or proliferation of a cd25 expressing cell, method for eliminating a cd25 expressing cell, method for treating or preventing a disorder involving cd25 expressing cells, method and diagnostic kit for detecting the presence of cd25 antigen or a cd25 expressing cell, vector of expression, anti-idiotic antibody, and use of it

摘要

"ANTIBODY HUMAN ISOLATED hybridoma, transfectoma, host cell eukaryotic or prokaryotic, NOT HUMAN ANIMAL OR PLANT GM, METHOD FOR PRODUCING A MONOCLONAL HUMAN, COMPOSITION, immunoconjugate molecule bispecific OR multispecies, METHOD FOR INHIBITING DEVELOPMENT AND / OR PROLIFERATION A CELL EXPRESSING CD25, A METHOD FOR DELETING A CELL EXPRESSING CD25, A METHOD FOR TREATING OR AVOIDING A DISORDER INVOLVING CD25, A METHOD AND SET OF CD25 DIAGNOSIS FOR EXPRESSING A CD25 OF EXPRESSION, ANTI-IDIOTITIC ANTIBODY, AND, USE THEREOF ". Isolated human monoclonal antibodies that bind to and inhibit human CD25 and compositions based on related antibodies and molecules are disclosed. Human antibodies may be produced by a hybridoma, a transfectome or a non-human transgenic animal, for example a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies undergoing V-D-J recombination and isotype change. Also disclosed are pharmaceutical compositions comprising human antibodies, non-human transgenic animals, hybridomas and transfectomas producing human antibodies, and therapeutic and diagnostic methods for using human antibodies.