BENZIMIDAZOLONE COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

摘要

Compounds which have activity at M1 receptor and their uses in medicineCompounds of formula (I) and salts and solvates are provided: wherein R4 isfluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkylsubstituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxysubstituted with one or more fluorine atoms; and R6 is selected from halogen,cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q ishydrogen or C1-6alkyl. The compounds are expected to be useful for therapy,for example in the treatment of psychotic disorders and cognitive impairment.