IMMUNOMODULATORY IL2R FUSION PROTEINS AND USES THEREOF

摘要

The present disclosure relates to fusion proteins containing an extracellular cytokine binding domain and an intracellular signaling domain of one or more IL-2R chains or signaling portion(s) thereof, wherein the cytokine binding domain is not an IL-2 binding domain. The present disclosure also relates to uses of immune cells expressing such fusion proteins to treat certain diseases, such as cancer or infectious disease.